Antibiotics Flashcards
What are common resistant pathogens?(kill each and every strong pathogen)
Are beta lactams time dependent?
Can you use penicillin G benzathine in an IV?
Klebsiella(ESBL,CRE), Escherichia Coli(ESBL CRE), Acinetobacter boumannii, Enterococcus Faecalis, Faecium, Staphylococcus Aureus, Pseudomonas Aeruginosa.
Yes
No!
What are the side effects of the penicillins?
How long is zosyn infused over?
What are your 1st generation cephalosporins?
Seizures(with accumulation), GI upset, diarrhea, rash.
4 hours.
Cefazoline, Cephalexin(keflex).
What are your 2nd and 3rd generation cephalosporins?
What are your 4th and 5th generation cephalosporins?
What are your side effects of ceftriaxone?
Cefuroxime(2nd), Cefdinir, Ceftriaxone, Cefatzidime(all 3rd).
Cefepime, Ceftaroline(Teflaro).
Ceftriaxone: Ci’d in neonates with lots of billirubin(sludging), concurrent use with calcium containing IV products in neonates <28 days.
What cephalosporin can cause a disulfiram like reaction?
What are some special things to know about the cephalosporins?
Which carbapenem has no pseudomonas coverage?
Cefotetan
Ceftriaxone requires no renal adjustment, Cefixime is in a chewable tablet, CRE coverage from Ceftazidime.
Ertapenem.
What are the big side effects of carbapenems?
What do carbapenems not cover?
What are the side effects of the aminoglycosides?
SEIZURES.
MRSA, Atypicals, VRE, C.diff. Ertapenem does not cover PEA
Nephrotoxicity, Ototoxicity, avoid use with other neurotoxic/nephrotoxic drugs, neuromuscular blockade. Primarily work on gram negatives(except pseudomonas).
What is your target trough for gentamycin and tobramycin?
What are the boxed warnings of the FQ’s?
What are warnings with FQ’s?
<2mcg/mL.
Tendon inflammation and rupture, peripheral neuropathy, seizures.
QT prolongation(moxi is worst), hypo and hyperglycemia, pschiatric disturbancem avoid in children, photosensitivity.
Which is the only quinolone you can’t use in UTI’s and should you avoid antacids?
Which FQ doesn’t cover respiratory bugs and which one doesn’t cover pseudomonas?
Which drug is not renally adjusted and which ones are IV to PO 1:1?
Moxifloxacin, YES! Including lanthanum and sevelamer.
Ciprofloxacin, Moxifloxacin.
Moxi, Levo and Moxi.
What is Zpak and Tripak’s dosing?
What are the side effects for the macrolides(50s)?
What to know about tetracyclines?
Zpak- 500 mg on day 1, then 250 days 2-5. Tri pak is 500 for 3 days.
do not use with lovastatin or simvastatin, QT prolongation, hepatoxicity, CAD watch clarithromycin, GI upset.
Children <8years, pregnancy, breastfeeding AVOID. Photosensitivity, Minocycline can cause DILE(lupus). IV: PO is 1:1.
Which antibiotic drug class should you avoid antacids and dairy products?
What things to know about Bactrim?
What to know about Vancomycin?
Tetracyclines
Dosed based on the Trimethoprim part, Increased INR when used with Warfarin, Watch for skin reactions, G6PD deficiency, sulfa allergy, photosensitivity, increased potassium and hemolytic anemia(coombs test positive), as well as crystalluria. Uncomplicated UTI dosing is 1DS tablet PO BID for 3 days.
Oto and nephro watch out as well as redman syndrome if infused too fast. 15-20 goal if serious infection, dose based on actual body weight.
