Gout Flashcards
What are normal serum UA levels?
What foods to avoid in gout?
What drugs increase uric acid?
2-6.5 mg/dL in females, 3.5-7.2 in males.
organ meats, high-fructose corn syrup, and alcohol.
Aspirin(higher doses), Diuretics(loops and thiazides), niacin, pyrazinamide, select pancreatic enzymes, calcineurin inhibitors, select chemo.
What is acute gout attack therapy?
What to know about Colchicine(colcrys)?
What NSAIDs treat gout?
Colchicine(Colcrys), NSAIDs or steroids.
two 0.6 mg tabs, 0.6 mg in 1 hour, not to exceed 1.8 mg in 1 hour. P-gp or strong cyp3a4 inhibitor CI. GI symptoms, increased myopathy risk, diarrhea, nausea, myelosuppression, myopathy, neuropathy. Start within 36 hours of symptoms, wait 12 hours before resuming prophylactic dose.
Indomethacin(Indocin), Naproxen. Avoid in severe renal disease, CVD risk.
What steroids help with gout?
What to know about Allopurinol?
What to know about Febuxostat?
Prednisone/Prednisolone. Methylprednisolone (Medrol). Intra articular: if 1-2 large joints involved.
Zyloprim, Aloprim. Hypersensitive reactions, severe rash, HLA-b 5801 testing prior to use, hepatotoxicity, rash, acute gout attacks, nausea, use with colchicine or an nsaid for the first 3-6 months.
Hepatotoxicity, thromboembolic events, serious skin reactions, increased LFT’s, use with colchicine or an nsaid for the first 3-6 months.
What are the uricosurics and what to know about them?
How does pegloticase work?
What are the XOI’s drug interactions?
Lesinurad, Probenecid. USe lesinurad with allopurinol or febuxostat, increased SCr with lesinurad(zurampic), Use only with XOI if can’t reach goals alone. Probenecid is a G6PD deficiency drug. Probenecid can be used to increase beta lactam levels. These drugs inhibit reabsorption of uric acid.
IV, converts uric acid to allantoin. BBW of anaphylactic reactions and premedicate with antihistamines and steroids. Do not use in combination with allopurinol or febuxostat.
Mercaptopurine, azathioprine, do not use with allopurinol or febuxostat.
