Non-Sterile Compounding

Question 1

Where are basic practices for non-sterile and sterile compounding found?

Are glass or porcelain mortars preferred for liquids?

What’s a glidant/lubricant?

Answer 1

USP 795

Glass

Magnesium stearate

Question 2

What is an example if a surfactant and what does it do?

What are your absorbent powders used with eutectic mixtures?

What are your troche bases?

Answer 2

Neutralizes static charge, Sodium lauryl sulfate

Magnesium oxide, Magnesium carbonate, or Kaolin.

Sucrose or syrup for hard lozenges, PEG for soft lozenges, glycerin or gelatin for chewable lozenges.

Question 3

What’s the HLB number?

Example of an anti foaming agent?

Example of an antioxidant?

Answer 3

0-20, midpoint is 10. Lower is more lipid soluble, higher is more water soluble

Simethicone

Ascorbic Acid

Question 4

Example of coatings?

Example of diluents(fillers)?

Example of a disintegrant?

Answer 4

Shellac, gelatin, gluten.

Lactose, starches, calcium salts, mannitol, sorbitol, cellulose

Alginic acid, polacrilin potassium(amberlite), cellulose products, starches(nu-tab)

Question 5

Example of an emollient?

Example of an enteric-coating?

Examples of sweeteners?

Answer 5

Petroleum jelly(petrolatum)

Cellulose acetate phthalate, Shellac

Sugar-free artificial(aspartame, saccharin), glycerin, dextrose, lactose, mannitol, sorbitol, phenylalanine, stevia, xylitol

Question 6

Examples of gelling agent or stabilizer?

Glidant example?

Hydrophilic solvent?

Answer 6

Gelatin, bentonite, agar, alginates, various gums, gelatins, tragacanth, bentonite, carbomer, cellulose, starches

Colloidal silica, magnesium stearate

PEG, alcohols(mixes easily with water)

Question 7

Hydrophobic solvent?

Levigating agent?

Lubricant?

Answer 7

Oils, fats

Mineral oil, glycerin

Magnesium stearate

Question 8

Preservative?

Suppository base?

Water?

Answer 8

Chlorhexidine, EDTA, sodium benzoate, benzoic acid, benzalkonium chloride, thimerosal

Hydrogenated vegetable oils, gelatin

Distilled or purified for reconstitution, portable water for hand washing and initial cleaning

Question 9

Nonaqueous formulations BUD?

Water-containing oral formulations?

Water-containing topical/dermal and mucosal liquid and semisolid formulations(cream or lotion)?

Answer 9

Any API or 6 months

14 days store in refrigerator

No later than 30 days.