Rotenone Flashcards
What are the properties of Rotenone?
Odorless Colorless crystalline ketonic chemical Readily degrade upon exposure to warm air and light Lipophilic
What is Rotenone used for?
Piscicide to kill fish - kills all fish and is not specific
What method of exposure to Rotenone is more toxic?
Inhalation
How long does it take for Rotenone to be excreted?
24 hours
What is the route of exposure in fish?
gills or trachea
What is the most common route of exposure of Rotenone in mammals?
Through the gut
What is the mechanism of action of Rotenone?
Blocks oxidative phosphorylation in the TCA cycle
Interferes with NADH in the electron transport chain
Oxygen is reduced to a reactive oxygen species (ROS)
Oxidative stress results in neuronal apoptosis
Clinical signs of Rotenone toxicosis?
Irritant - conjunctivitis, congestion, dermatitis, etc neurotoxin depression convulsions muscle tremors lethargy respiratory depression asphyxia
What tissues should be tested for Rotenone?
Stomach contents
Urine
feces
liver
What clinical pathology findings will you see with Rotenone?
Hypoglycemia
Liver enzyme changes
Hypoxemia/hypercapnia
What is the treatment for Rotenone?
Detoxification
Supportive treatment
What is the prognosis of Rotenone in mammals?
Good
What is the prognosis of Rotenone in fish, reptiles, amphibians, and insects?
Poor prognosis
