DEET Flashcards
1
Q
What is a common use of DEET?
A
Insect repellant
2
Q
What is the Acute oral LD50 in rats for DEET?
A
2g/kg
3
Q
What is the acute dermal LD50 in rabbits for DEET?
A
3g/kg
4
Q
DEET toxicokinetics
A
Absorbed through the skin
can increase dermal absorption of other products
Metabolized inthe liver and excreted in urine
5
Q
What are the clinical signs of DEET?
A
Rats and Rabbits: Depression excitation ataxia tremors seizures coma
Dogs and Cats: Salivation Vomiting hyperexcitability tremors ataxia seizures
6
Q
What should chemical analysis be used on to detect DEET?
A
stomach contents urine blood skin vitreous humor bile kidney
7
Q
What is considered diagnostic for DEET?
A
20ppm
Urine concentrations greater than 1ppm
tissue greater than 10ppm
8
Q
Treatment for DEET?
A
No specific antidote
Decontamination: Emesis, Activated Charcoal
Symptomatic treatment
9
Q
What is the prognosis for DEET?
A
Good - respond in 24-72hours
