Amitraz

Question 1

What is Amitraz used for?

Answer 1

flea and tick collars

Question 2

How does Amitraz work?

Answer 2

paralyzes the mouth parts

Question 3

What species is Amitraz contraindicated in?

Answer 3

Cats

Horses

Question 4

What is the mechanism of action for Amitraz?

Answer 4

Alpha 2 adrenergic agonist in the CNS
Weak alpha 1 agonist
Weak Monoamine Oxidase (MAO) inhibitor

Question 5

What increases toxicity of Amitraz?

Answer 5

Meperidine and sympathomimetic amines

Question 6

what is the acute LD50 of Amitraz in dogs?

Answer 6

250 mg/kg

Question 7

What is the dose of Amitraz for sedation in dogs?

Answer 7

20mg/kg

Question 8

How is Amitraz readily absorbed?

Answer 8

orally
inhalation
dermally

Question 9

What is the elimination half life of Amitraz?

Answer 9

24 hours

Question 10

Amitraz toxicokinetics

Answer 10

distributed throughout the body and CNS
metabolized by the liver
excreted in the urine

Question 11

Amitraz clinical signs?

Answer 11

Transient sedation for 24-72 hours
lethargy 
ataxia
bradycardia
depression 
vomiting
dyspnea
hypothermia
tremors
seizures
Cardiovascular collapse
Respiratory failure
Hyperglycemia

Question 12

What can be analyzed for Amitraz?

Answer 12

Liver 
Kidney 
Brain 
Adipose
Plasma
Urine
blood 
stomach contents

Question 13

What is the treatment for Amitraz toxicosis?

Answer 13

Alpha 2 antagonists
Decontamination: Washing or Emesis
Supportive Care

Question 14

What drugs are the antidote for Amitraz?

Answer 14

Alpha 2 antagonists: yohimbine & atipamezole

Question 15

What is the prognosis for Amitraz toxicosis?

Answer 15

Good