Napthalene Flashcards
What is the most common Napthalene product?
Mothballs
What are the two versions of mothballs?
Naphthalene
Paradichlorobenzene
What is Naphthalene derived from?
Crude oil or coal tar
Naphthalene properties
volatile and will sublimate to a toxic gas at room temperature
Irritant
How are animals exposed to Naphthalene?
Orally
Dermally
Ingestion
What is Naphthalene solubility?
Lipid soluble
Where is Naphthalene found in high concentrations?
Adipose tissues
kidneys
liver
lungs
Naphthalene toxicokinetics
excrete in milk
crosses the placenta
Naphthalene Mechanism of Action
Oxidation products cause hemolytic anemia and methemoglobinemia
Metabolites form epoxides or quinones causing hemolysis
Excrete through urine and bile
Naphthalene Clinical Signs
Dissolve slowly in the stomach so can be delayed by several days: Vomiting Mothball scented breath Pale or brown gums weakness or lethargy Labored breathing tremors seizures Possible Liver or Kidney damage
What the lesions seen with Naphthalene toxicosis?
Methemoglobinemia
Hemolysis
Heinz bodies
Hemoglobinuria
What is the treatment for Naphthalene toxicosis?
Decontamination: Emesis, Activated Charcoal
Ascorbic Acid
IV Fluids
Sodium bicarbonate
How do you convert methemoglobin to hemoglobin?
Ascorbic Acid
Methylene Blue
What is the prognosis for animal treated promptly and with no pre-existing disease for Naphthalene toxicosis?
Good
