Respiratory (Inhaled Corticosteroids)

Question 1

Examples of drug (Inhaled Corticosteroids)

Answer 1

• Beclomethasone
• Note that some inhaled preparations used in COPD and asthma contain both inhaled steroids and long acting bronchodilators (examples are Seretide and Symbicort).

Question 2

Mechanism of action (Inhaled Corticosteroids)

Answer 2

• Anti-inflammatory effect on the airways.
• Decrease formation of pro-inflammatory cytokines.
• Up-regulates beta-2-adrenoreceptors in airways.

Question 3

Indications (Inhaled Corticosteroids)

Answer 3

• Treatrment of COPD

- Treatment of asthma

Question 4

Side effects (Inhaled Corticosteroids)

Answer 4

• Oral Candidiasis (thrush)
• Adrenal suppression
• Osteoporosis

Question 5

Important pharmacokinetics/pharmacodynamics (Inhaled Corticosteroids)

Answer 5

• Takes several weeks to months for full effects of therapy.

- Spacer devices can reduce risk of thrush and improve drug delivery.

Question 6

Patient information (Inhaled Corticosteroids)

Answer 6

• If on higher dose, carry a steroid card.

- Increase dose during periods of illness.