Endocrine (Sulphonylureas)

Question 1

Examples of drug (Sulphonylureas)

Answer 1

• Gliclazide

- Glimepiride

Question 2

Mechanism of action (Sulphonylureas)

Answer 2

• Stimulates B cells of the pancreas to produce more insulin
• Increase cellular glucose uptake and glycogenesis; reduces gluconeogenesis
• Glicazide is short acting (12 hours approx)

Question 3

Indications (Sulphonylureas)

Answer 3

• Type 2 diabetes mellitus along with diet and exercise

Question 4

Side-effects (Sulphonylureas)

Answer 4

• Hypoglycaemia
• Rashes
• Nausea
• Vomiting
• Stomach pain
• Indigestion
• Weight gain

Question 5

Important pharmacokinetics/pharmacodynamics (Sulphonylureas)

Answer 5

• Renally excreted so accumulate in renal failure

- Glimepiride is long acting sulphonylureas

Question 6

Patient information (Sulphonylureas)

Answer 6

• Compliance important
• Maintain consistent diet
• Avoid alcohol