MSK (Opiates - Oxycodone)

Question 1

Examples of drug (Opiates - Oxycodone)

Answer 1

• Oxycodone

Question 2

Mechanism of action (Opiates - Oxycodone)

Answer 2

• Opioid receptor agonist; acts on mu, kappa and delta on presynaptic neurones. This gives numerous effects that increase nociceptive thresholds throughout the central and peripheral nervous system.

Question 3

Indications (Opiates - Oxycodone)

Answer 3

• Moderate to severe pain relief in cancer patients
• Postoperative pain
• Severe pain

Question 4

Side effects (Opiates - Oxycodone)

Answer 4

• Nausea
• Vomiting
• Abdominal pain
• Constipation

Question 5

Important pharmacokinetics/pharmacodynamics (Opiates - Oxycodone)

Answer 5

• Available as long and short acting preparations
• Predominantly metabolised by the liver.
• Often administered via slow intravenous/subcutaneous infusion.

Question 6

Patient information (Opiates - Oxycodone)

Answer 6

• Nausea and constipation are common side-effects.