Respiratory (Anti-Muscarinic Bronchodilators)

Question 1

Examples of drug (Anti-Muscarinic Bronchodilators)

Answer 1

• Tiotropium

- Ipratropium Bromide

Question 2

Mechanism of action (Anti-Muscarinic Bronchodilators)

Answer 2

• Muscarinic receptor (M3) antagonists producing bronchodilatory effects.
• Reduces mucus secretion and may increase bronchial mucus clearance by stimulating cilia.

Question 3

Indications (Anti-Muscarinic Bronchodilators)

Answer 3

• Asthma
• COPD
• Rhinitis

Question 4

Side effects (Anti-Muscarinic Bronchodilators)

Answer 4

• Dry mouth
• Cough
• Constipation

Question 5

Important pharmacokinetics/pharmacodynamics (Anti-Muscarinic Bronchodilators)

Answer 5

• Inhaled and poorly absorbed into the circulation – unable to affect systemic muscarinic/cholinergic receptors
• Nebulised Ipratropium Bromide should always be administered via a mouth piece to minimize the risk of acute angle closure glaucoma.

Question 6

Patient information (Anti-Muscarinic Bronchodilators)

Answer 6

• Good inhaler technique improves efficacy.

- Cough may arise.