Haematological (Factor Xa Antagonists - Rivaroxaban)

Question 1

Examples of drug (Factor Xa Antagonists - Rivaroxaban)

Answer 1

• Rivaroxaban

Question 2

Mechanism of action (Factor Xa Antagonists - Rivaroxaban)

Answer 2

• Inhibits conversion of prothrombin to thrombin, reducing concentrations of thrombin in the blood.
• This inhibits the formation of fibrin clots.

Question 3

Indicatons (Factor Xa Antagonists - Rivaroxaban)

Answer 3

• Prophylaxis of venous thromboembolism (especially post-operative)
• Thromboprophylaxis in non-valvular AF
• Treatment of venous thromboembolism

Question 4

Side effects (Factor Xa Antagonists - Rivaroxaban)

Answer 4

• Bleeding

- Nausea

Question 5

Important pharmacokinetics/pharmacodynamics (Factor Xa Antagonists - Rivaroxaban)

Answer 5

-
Predictable drug interactions (metabolised via CYP 450, inc CYP3A4)
- No need for therapeutic monitoring
- Currently no available antidote

Question 6

Patient information (Factor Xa Antagonists - Rivaroxaban)

Answer 6

• Risk of bleeding