Gastrointestinal (Anti-Emetic Drugs - Prochlorperazine)

Question 1

Examples of drug (Anti-Emetic Drugs - Prochlorperazine)

Answer 1

• Prochlorperazine

Question 2

Mechanism of action (Anti-Emetic Drugs - Prochlorperazine)

Answer 2

• Penothiazine anti-psychotic drug used as an anti-emetic
• Dopamine (D2) receptor antagonist
• Causes increased dopamine turnover (in mesolimbic and chemoreceptor trigger zone)

Question 3

Indications (Anti-Emetic Drugs - Prochlorperazine)

Answer 3

• Nausea and vomiting

- Used as an adjunct in some psychotic disorders

Question 4

Side-effects (Anti-Emetic Drugs - Prochlorperazine)

Answer 4

• Dry mouth
• Tachycardia
• Restlessness
• Drowsiness

Question 5

Important pharmacokinetics/pharmacodynamics (Anti-Emetic Drugs - Prochlorperazine)

Answer 5

-
Anticholinergic and alpha-adrenergic receptors antagonism occurs leading to; sedation, muscle relaxation, and hypotension.
- The dose differs substantially when given parenterally

Question 6

Patient information (Anti-Emetic Drugs - Prochlorperazine)

Answer 6

• Avoid alcohol and caffeine

- Take with food along with a full glass of water