Anti-infectives (Quinolones)

Question 1

Examples of drug (Quinolones)

Answer 1

• Ciprofloxacin

Question 2

Mechanism of action (Quinolones)

Answer 2

• Interferes with bacterial DNA replication and repair.

- Broad-spectrum bactericidal antibiotics; provides both gram-positive and gram-negative cover.

Question 3

Indications (Quinolones)

Answer 3

• Gram negative bacterial infection
• Respiratory tract infection
• Upper urinary tract infection
• Peritoneal infection
• Gonorrhoea
• Prostatitis

Question 4

Side effects (Quinolones)

Answer 4

• GI toxicity
• QT wave prolongation
• Clostridium difficile infection (antibiotic associated diarrhoea)
• Tendonitis (this is extremely rare, but is an example of a type B adverse drug reaction)

Question 5

Patient information (Quinolones)

Answer 5

• Risk of diarrhoea after use.