Endocrine (Synthetic Thyroid Hormone)

Question 1

Examples of drug (Synthetic Thyroid Hormone)

Answer 1

• Levothyroxine

Question 2

Mechanism of action (Synthetic Thyroid Hormone)

Answer 2

• Thyroxine increases the metabolic rate of all tissues in the body
• Synthetically prepared levo-isomer of thyroxine
• Acts like T4 and gets converted to T3 in the liver and kidney
• Maintain brain function, food metabolism, and body temperature, among other effects

Question 3

Indications (Synthetic Thyroid Hormone)

Answer 3

• Hypothyroidism

- Chronic lymphocytic thyroiditis

Question 4

Side-effects (Synthetic Thyroid Hormone)

Answer 4

• Chest pain
• Coma
• Diarrhoea
• Tachycardia
• Itching
• Muscle cramps
• If dosing is correct, side effects are unusual.

Question 5

Important pharmacokinetics/pharmacodynamics (Synthetic Thyroid Hormone)

Answer 5

• ## Primarily eliminated by the kidneysIntravenous formulations are available
• The half-life is long (6 to 7 days) so thyroid function should be rechecked 6 weeks after a dose adjustment

Question 6

Patient information (Synthetic Thyroid Hormone)

Answer 6

• Take 30-60 minutes before breakfast.