Haematological (Anti-Platelet Drugs - Clopidogrel)

Question 1

Examples of drug (Anti-Platelet Drugs - Clopidogrel)

Answer 1

• Clopidogrel

Question 2

Mechanism of action (Anti-Platelet Drugs - Clopidogrel)

Answer 2

• Irreversibly blocks the ADP-receptor on platelet cell membranes.
• Consequently inhibits formation of GPIIb/IIIa complex, required for platelet aggregation.
• Decreased thrombus formation.

Question 3

Indications (Anti-Platelet Drugs - Clopidogrel)

Answer 3

• Secondary prevention of thrombotic events

Question 4

Side effects (Anti-Platelet Drugs - Clopidogrel)

Answer 4

• Bleeding (1-10% of Patients)

- Abdominal pain / diarrhoea (1-10% of Patients)

Question 5

Important pharmacokinetics/pharmacodynamics (Anti-Platelet Drugs - Clopidogrel)

Answer 5

• Avoid in liver failure

Question 6

Patient information (Anti-Platelet Drugs - Clopidogrel)

Answer 6

• Patients may be advised to stop clopidogrel before surgical procedures.
• Patients should not stop clopidogrel without consulting their doctor if they have an arterial stent in-situ.