Haematological (Factor Xa Antagonist - Apixaban)

Question 1

Examples of drug (Factor Xa Antagonist -

Apixaban)

Answer 1

• Apixaban

Question 2

Mechanism of action (Factor Xa Antagonist -

Apixaban)

Answer 2

• Inhibits conversion of prothrombin to thrombin; reducing concentrations of thrombin in the blood.
• This inhibits the formation of fibrin clots.

Question 3

Indications (Factor Xa Antagonist -

Apixaban)

Answer 3

• Prophylaxis of venous thromboembolism following hip or knee replacement surgery.
• Thromboprophylaxis in non-valvular AF.

Question 4

Side effects (Factor Xa Antagonist -
 Apixaban)

Answer 4

• Bleeding

- Nausea

Question 5

Important pharmacokinetics/pharmacodynamics (Factor Xa Antagonist -
Apixaban)

Answer 5

-
Predictable drug interactions (metabolised via CYP 450 and substrate for p glycoprotein)
- 75% is metabolised by the liver, the rest being renally excreted.
- No need for therapeutic monitoring
- Currently no available antidote.

Question 6

Patient information (Factor Xa Antagonist -
 Apixaban)

Answer 6

• Risk of bleeding