Endocrine (Bisphosphates)

Question 1

Examples of drug (Bisphosphates)

Answer 1

• Alendronate (Alendronic Acid)

- Ibandronate

Question 2

Mechanism of action (Bisphosphates)

Answer 2

• Inhibits osteoclast bone resorption

- No effect on bone formation

Question 3

Indications (Bisphosphates)

Answer 3

• Post menopausal osteoporosis
• Reduces risk of vertebral and hip fractures
• Paget’s disease of bone

Question 4

Side-effects (Bisphosphates)

Answer 4

• Abdominal pain
• Dyspepsia
• Acid regurgitation
• Dysphagia
• Headache

Question 5

Important pharmacokinetics/pharmacodynamics (Bisphosphates)

Answer 5

• Bioavailability reduces with breakfast (with coffee or orange juice)

Question 6

Patient information (Bisphosphates)

Answer 6

• Administer 30 mins before food

- Avoid caffeine