Endocrine (GLP-1 (glucagon like peptide) Agonist)

Question 1

Examples of drug (GLP-1 (glucagon like peptide) Agonist)

Answer 1

• Exanatide

- Liraglutide

Question 2

Mechanism of action (GLP-1 (glucagon like peptide) Agonist)

Answer 2

• GLP-1 is a hormone that is released after meals to increase insulin secretion
• These drugs are a GLP-1 agonist
• It increases insulin secretion, decreases glucagon secretion and reduces hunger

Question 3

Indications (GLP-1 (glucagon like peptide) Agonist)

Answer 3

• Type 2 Diabetes Mellitus (in association with excess weight).

Question 4

Side-effects (GLP-1 (glucagon like peptide) Agonist)

Answer 4

• Hypoglycaemia
• Nausea
• Vomiting
• Diarrhoea

Question 5

Important pharmacokinetics/pharmacodynamics (GLP-1 (glucagon like peptide) Agonist)

Answer 5

• It can lower glucose alone, but when given in combination with metformin, sulfonylureas, and/or insulin it can improve glucose control
• Renally excreted so dose adjustment needed in renal failure

Question 6

Patient information (GLP-1 (glucagon like peptide) Agonist)

Answer 6

• Only given as injections

- Twice a day