Anti-infectives (Macrolides)

Question 1

Examples of drug (Macrolides)

Answer 1

• Clarithromycin

- Erythromycin

Question 2

Mechanism of action (Macrolides)

Answer 2

• Binds to 50s ribosomal subunit

- Inhibits bacterial protein synthesis.

Question 3

Indications (Macrolides)

Answer 3

• Atypical organisms causing pneumonia / Severe CAP
• Severe campylobacter infection
• Mild / moderate SSTI
• Otitis media
• Lyme disease
• Helicobacter pylori eradication therapy

Question 4

Side effects (Macrolides)

Answer 4

• Diarrhoea
• Vomiting
• QT wave prolongation
• Ototoxicity with long-term use

Question 5

Important pharmacokinetics/pharmacodynamics (Macrolides)

Answer 5

• Uses hepatic enzyme Cytochrome P450 pathway

- Can interact with all drugs using this pathway, especially Simvastatin, Atorvastatin and Warfarin.

Question 6

Patient information (Macrolides)

Answer 6

• Risk of Diarrhoea
• Senses of smell and taste may be disturbed during therapy.
• Tooth and tongue discoloration may occur during therapy.