Endocrine (Biguanides) Flashcards
1
Q
Examples of drug (Biguanides)
A
- Metformin
2
Q
Mechanism of action (Biguanides)
A
- Increase the activity of AMP-dependent protein kinase (AMPK)
- This inhibits gluconeogenesis
- Reduces insulin resistance
3
Q
Indications (Biguanides)
A
- Type 2 diabetes mellitus along with diet and exercise
- Metabolic and reproductive abnormalities associated with Polycystic ovarian syndrome
4
Q
Side-effects (Biguanides)
A
- Diarrhoea
- Nausea
- Vomiting
- Taste disturbances
- Lack of appetite
- Risk of lactic acidosis in patients with renal failure
5
Q
Important pharmacokinetics/pharmacodynamics (Biguanides)
A
- Not recommended in pregnancy and renal failure (eGFR <30 mls/min)
- Absorption reduces when taken with food
6
Q
Patient information (Biguanides)
A
- Take them at the same time everyday
- Avoid alcohol
7
Q
Other information (Biguanides)
A
- Does not increase weight
