Neurological (Anti-Psychotic Drugs)

Question 1

Examples of drug (Anti-Psychotic Drugs)

Answer 1

• First generation anti-psychotics act non selectively on D1-like and D2-like receptors (Haloperidol, Chlorpromazine)
• Atypical anti-psychotics have varying effects on dopamine and serotonin receptors (Olanzapine, Clozapine)

Question 2

Mechanism of action (Anti-Psychotic Drugs)

Answer 2

• Block dopamine receptors
• Action on mesolimbic and nigrostriatal parts of brain
• Also have anti-histaminergic and anti-cholinergic effects
• These effects reduce positive symptoms of schizophrenia and can cause sedation and provide anti-emetic activity.

Question 3

Indications (Anti-Psychotic Drugs)

Answer 3

• Schizophrenia
• Mania
• Delusions, hallucinations
• Behavioral problems
• Anti-emetic (Haloperidol)

Question 4

Side effects (Anti-Psychotic Drugs)

Answer 4

• Sedation (anti-histaminergic effect)
• Postural hypotension, tachycardia (anti-adrenergic effect)
• Urinary retention, dry mouth, blurry vision (anti-cholinergic effect)

Question 5

Important pharmacokinetics/pharmacodynamics (Anti-Psychotic Drugs)

Answer 5

• Have effects on numerous receptor systems within the central nervous system.

Question 6

Patient information (Anti-Psychotic Drugs)

Answer 6

• Symptoms may not always disappear while on medication

- Dosage may have to be increased if no improvement after a few weeks