Renal (Loop Diuretics)

Question 1

Examples of drug (Loop Diuretics)

Answer 1

• Furosemide
• Bumetanide
• Torasemide

Question 2

Mechanism of action (Loop Diuretics)

Answer 2

• Na+/Cl-/K+ symporter antagonists
• Act on the thick ascending loop of Henle
• Increase secretion of Na+, K+, Cl- and water

Question 3

Indications (Loop Diuretics)

Answer 3

• Hypertension
• Hyperkalaemia
• Heart failure
• Cirrhosis of liver (fluid retention)
• Nephrotic syndrome

Question 4

Side effects (Loop Diuretics)

Answer 4

• Hypokalaemia, hypovolaemia, hyperuricaemia (increased urate reabsorption)
• Metabolic acidosis
• Abdominal pain
• Ototoxicity

Question 5

Important pharmacokinetics/pharmacodynamics (Loop Diuretics)

Answer 5

• 60% absorbed in patients with normal renal function

- Renal and hepatic excretion – increased half-life for patients with renal or hepatic disease

Question 6

Patient information (Loop Diuretics)

Answer 6

• Avoid excess alcohol

- Urinary frequency increases