Neurological (Anti-Epileptic Drugs - Lamotrigrine)

Question 1

Examples of drug (Anti-Epileptic Drugs - Lamotrigrine)

Answer 1

• Lamotrigrine

Question 2

Mechanism of action (Anti-Epileptic Drugs - Lamotrigrine)

Answer 2

• Varied mechanism of action
• Inhibits voltage-gated Na+ channels and/or Ca2+ channels
• Acts on pre-synaptic neuronal membrane
• Reduces action potential and excitatory signals

Question 3

Indications (Anti-Epileptic Drugs - Lamotrigrine)

Answer 3

• Epilepsy (used for both partial and generalized seizures)

- Depressive episodes associated with Bipolar disorder

Question 4

Side effects (Anti-Epileptic Drugs - Lamotrigrine)

Answer 4

• Nausea
• Vomiting
• Diarrhoea
• Tremor
• Insomnia
• Blurred vision
• Aggression
• Skin reactions including Sevens-Johnson syndrome and toxic epidermal necrolysis (rarely)

Question 5

Important pharmacokinetics/pharmacodynamics (Anti-Epileptic Drugs - Lamotrigrine)

Answer 5

• Half-life doubles in chronic renal impairment so dose adjustment is required.

Question 6

Patient information (Anti-Epileptic Drugs - Lamotrigrine)

Answer 6

• Take without regard to meals

- Seek medical advice if any rash or signs/symptoms of hypersensitivity.