Gastrointestinal (Proton Pump Inhibitors)

Question 1

Examples of drug (Proton Pump Inhibitors)

Answer 1

• Omeprazole
• Lansoprazole
• Pantoprazole

Question 2

Mechanism of action (Proton Pump Inhibitors)

Answer 2

• Bind to H+/K+ ATPase pump on gastric parietal cells

- Reduces HCl production and hence reduced gastric acidity

Question 3

Indications (Proton Pump Inhibitors)

Answer 3

• Peptic ulcers
• Gastro-oesophageal reflux disease
• H.Pylori infection
• Prophylaxis in patients receiving long term NSAIDs
• Zollinger-Ellison syndrome

Question 4

Side-effects (Proton Pump Inhibitors)

Answer 4

• Nausea
• Vomiting
• Insomnia
• Vertigo
• Headaches

Question 5

Important pharmacokinetics/pharmacodynamics (Proton Pump Inhibitors)

Answer 5

• Omeprazole is an inhibitor of cytochrome P450 enzymes

Question 6

Patient information (Proton Pump Inhibitors)

Answer 6

• Avoid alcohol

- Take 30-60mins before food