Regulation of Gene Expression Flashcards
What is the number of different cell types in the humans?
200 different cell types.
What is the human tissue proteome?
Map of expression in 32 human tissues - The corresponding proteins which are localised are the proteomes.
What are the housekeeping genes?
Proteins essential for ALL cells.
The basic cellular function is expressed in EVERY cell type in an organism.
What is the number of housekeeping genes?
7319 protein coding genes.
Where are tissue elevated genes found?
Found in the duodenum = Small Intestine.
This aids with food breakdown.
What is the overview of gene expression regulation?
DNA Primary mRNA transcript mRNA Protein Modified Protein
Where does DNA / Histone modification occur?
DNA
Between which 2 stages does RNA processing control occur?
Primary mRNA transcript.
Between which 2 stages does transcriptional control occur?
DNA and primary mRNA transcript.
Between which 2 stages does post - transcriptional control occur?
mRNA and protein.
Between which 2 stages does protein modification occur?
Protein and Modified Protein.
What regulates the transcription of genes?
Transcription Factors.
What do the transcriptional factors bind onto?
Bind to DNA in order to turn genes on or off.
What are the factors which turn genes on and off?
Activators // Repressors.
What happens when the DNA loops around?
Allows interactions between transcription factors and the core promoter region.
