Body Compartments and Drug Movement C Flashcards
Which transporters do drugs use?
Lipid - Insoluble drugs are carried by transporters of physiologically important molecules.
Name the 3 main pumps used to transport drugs.
- Uniporter
- Anitporter
- Symporter
What is an uniporter?
Travels in one direction.
The direction is determined by the concentration gradient.
What is an antiporter?
This is where one molecule is swapped for another.
What is a symporter?
This is where the drug and molecule are transported together.
What process is used by uniporter?
Facilitated Diffusion.
What process is used by the antiporter and symporter?
Secondary Active Transporter (energy dependent carriers)
What is an Efflux Pump?
Process of ATP to ADP conversion.
What process is used by an Efflux Pump?
Primary Active Transporter (ATP dependent carriers)
What is the category uniporters / antiporters / symporters come under?
SLC carriers (solute carriers)
What is the category that Efflux pumps fall into?
ABC carriers (ATP binding cassettes)
What two categories do solute carriers fall into?
Organic cation transporters = Drugs which are weak bases
Organic anion transporters = Drugs which are weak acids
What processes do solute carriers undertake?
Facilitates diffusion or secondary active transport.
What is the purpose of p - glycoprotein transporters (P-gp) ?
Pumps many foreign substances out of cells and thus, reduce drug concentration at treatment target.
This, in turn, reduces efficacy.
Also, can transport many DIFFERENT drugs.
What can the function of P-gp transporters be impaired by?
Drugs which block the transporter function.
Mutations which change transporter function.
