psychopathology- biological approach to explaining and treating ocd Flashcards

ao1 done for both, ao3 for treating done

1
Q

what are the 2 genetic explanations

A

COMT gene
SERT gene
diathesis stress

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2
Q

the genetic explanations focus on the meaning that individuals inherit ….

A

specific genes from their parents that are related to the onset of OCD

view that mental disorders/behaviour is determined and therefore explained through someones biology / genes

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3
Q

what is the comt gene explanation

A

it is involved in the productions of COMT which regulates the production of the neurotransmitter dopamine which is implicated in ocd.

one allele of the comt gene has been found to be more common in ocd patients that without people without.

this variation produces LOWER activity of the comt gene and so there are higher levels of dopamine

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4
Q

what is the SERT gene explanation

A

this gene affects the transport of serotonin > it creates lower levels of it

low levels of S are implicated in ocd.

one study found a mutation of this gene in two unrelated families where six of the seven family members had ocd

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5
Q

what is the diathesis stress explanation

A

a model that suggests that the presence of a specific gene allele/mutation only creates a vulnerability (diathesis) for ocd (as well as other conditions eg depression)

and that the condition only presents itself when prompted to by a stressor eg trauma

and so people might possess the comt/sert gene variations but have no symptoms because the condition hasnt been manifested

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6
Q

what are the 2 neural explanations

A

abnormal levels of neurotransmitters

abnormal brain circuits

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7
Q

what is the abnormal levels of neurotransmitters explanation (dopamine bit)

A

thought that abnormally high D levels in those with ocd.

this is based on animal studies where high doses of drugs that enhance D levels were injected and this induced stereotyped movements resembling the compulsive behaviours found in ocd patients

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8
Q

what is the abnormal levels of neurotransmitters explanation (serotonin bit)

A

lower levels of S are associated with ocd.

based on fact that antidepressant drugs that increase S activity have been shown to reduce ocd symptoms VS antidepressants that have less effect on S do not reduce ocd symptoms

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9
Q

what is the abnormal brain circuits explanation

(what are the parts, what is the worry circuit, how is it explained in pet scans)

A

several areas in the frontal lobe are abnormal in people with ocd

eg caudate nucleus

so orbitofrontal cortex DOES send signals to the thalamus about things that are worrying eg potential germ hazard

so when caudate nucleus is damages it fails to suppress minor “worry” signals and so thalamus IS alerted

this then sends signals back to ofc in a worry circuit

pet scan when ocd symptoms are active > shows more activity in ofc

active eg when a germ obsessive holds a dirty cloth

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10
Q

which neurotransmitter is associated with comt gene and the sert gene

A

comt- dopamine
sert-serotonin

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11
Q

what is the abnormal levels of dopamine explanation based on

A

animal studies

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12
Q

what is the abnormal levels of serotonin explanation based on

A

antidepressants

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13
Q

what does the caudate nucleus normally do

A

suppress signals from the orbitofrontal cortex (OFC)

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14
Q

what is involved in the worry circuit

A

orbitofrontal cortex (ofc) and thalamus

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15
Q

what is the abnormal brain circuits explanation based on

A

pet scans

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16
Q

what neurotransmitters are associated with the brain regions that are abnormal

A

serotonin > abnormal > caudate nucleus and ofc malfunction

dopamine for basal ganglia (containing caudate nucleus) abnormal levels > malfunction

17
Q

evaluation for explanation: a strength is the real world application (genome….. and gene ……)

cp also implies that…

A

rwa- genome mapping can link genes to specific disorders

done by screening fertilised eggs > give mother option to abort if they are predisposed to disorder (ocd)

AND: gene therapy can “turn off” certain genes so that the disorder does not present.

HOWEVER there are ethical issues with both > controversial

ALSO implies that the link between genes and disorders like ocd is simple when its not.

18
Q

evaluation for explanation: research support from family and twin studies (2 examples)

A

nestad family studies show a link between genetics and ocd

80 ocd patients and 343 1stdeg relatives and compared to 73 controls without mental illness and 300 of their relatives and FOUND people with a 1st degrel with ocd had a 5x greater risk of having ocd compared to controls

a meta analysis

22
Q

what is the biological approach to treating ocd

A

drug therapy

23
Q

what are the types of drug therapy for treating ocd

A

antidepressants (SSRIs and tricyclics)

antianxiety drugs

there are also some other drugs (antibiotic d-cycloserine)

24
Q

what does SSRI stand for

A

selective serotonin reuptake inhibitors

25
why are the antidepressants SSRIs used to treat ocd
both depression and ocd sufferers have low levels of serotonin, increasing S therefore treats both. increasing S normalises the worry circuit. used to reduce the anxiety associated with ocd. they increase levels of S which regulates mood and anxiety
26
how do SSRIs work at a synapse
S is released into synapse on one neurone and targets receptor cells on receiving neurone at receptor sites and is then reabsorbed by the initial neurone so taking an SSRI increases stimulation to the receiving neurone so the reuptake is inhibited
27
how do the antidepressants tricyclics work
they block the transporter mechanism that reabsorbs both S and noradrenaline into the presynaptic neurone. so more of the neurotransmitters are left in the synapse prolonging their effect and easing transmission of the next impulse. + they can target more than one neurotransmitter -greater side-effects so used if SSRIs are not effective
28
what are anti-anxiety drugs (benzodiazepines), how do they work
eg valium, xanax, diazepam they slow the activity of the cns by enhancing GABA, a neurotransmitter than when released has a quietening effect on the brain. because it reacts with GABA receptors on receiving neurones, so when GABA binds with receptor it opens chloride channel > chloride into neurone > makes it harder for neurone to be stimulated by another neurotransmitter > slowing activity > more relaxed
29
how can the antibiotic d-cycloserine be used for treating ocd
reduces anxiety so effective for ocd especially when used in conjunction with psychotherapy. it is normally used for tb treatment but has been seen to enhance GABA transmission > reduce anxiety
30
evaluation for treatment: evidence for effectiveness, research usually compares.... inc cp: the studies are only for ....
results of the drug with a placebo soomro reviewed 17 studies into the use of SSRIs > more effective than placebos up to 3 months after treatment in reducing ocd symptoms cp: studies are only for 3-4 months so there is a lack of lt data
31
evaluation for treatment: drug therapies vs cbt
drug therapies require little input from patient vs cbt which requires regular meetings and considerable thought (dt just require taking the meds) dt also cheaper for the nhs cus they require less monitoring and cost less patients may benefit from talking about ocd with doctor during consultations although dodo bird effect (regardless of therapy patient will get that benefit)
32
evaluation for treatment: limitation, SSRI and tricyclics, BZs side effects
can cause nausea, headache and insomnia > patient stops taking drug tricyclics more severe: hallucinations, irregular heartbeat BZs: aggressiveness and LT impairment of memory so use should be limited addictive > limits usefulness of drugs
33
evaluation for treatment: limitation of publication bias
possible bias printing studies with positive outcomes and not the ones with negative ones and republishing the good ones to make it look like more evidence has been found > docs making inappropriate decisions on treatment
34
evaluation for treatment: limitation not a lasting cure maina found ...
that patient relapse shortly after medication stops in a review sponsored by american psychiatric association suggested that cbt should be tried first
35