Prochlorperazine

Question 1

Prochlorperazine Trade Name?

Answer 1

Compazine

Question 2

Prochlorperazine Classification?

Answer 2

Antiemetic

Question 3

Prochlorperazine Mechanism?

Answer 3

Dopamine (D2) R antagonist - inhibits communication from the chemoreceptor trigger zone (which recognizes emetic toxins) to the vomiting center (4th ventricle) of the brain; inhibits gastric SMC relaxation, leading to increased motility of stomach contents into the small intestine; also has weak anticholinergic properties

Question 4

Prochlorperazine Indications?

Answer 4

Nausea/Vomiting
Migraine headache

Question 5

Prochlorperazine Contraindications?

Answer 5

-Hypersensitivity
-CNS Depression

Question 6

Prochlorperazine Side Effects/Precautions?

Answer 6

? Bradycardia
? Tachycardia
? Hypotension
? CNS Depression
? Sedation
? Drowsiness
? Dizziness
? Blurred Vision
? Extrapyramidal Symptoms (Akathisia, Parkinsonism, Or Dystonia)

Question 7

Prochlorperazine Adult Dose?

Answer 7

• Nausea/Vomiting: 5-10 mg IV/IO, or 5 mg IM; may repeat once after 10 minutes if nausea/vomiting persists.
• Migrane: 10 mg IV/IO infusion over 15 minutes or 10 mg IM.
  *CT Protocols

Question 8

Prochlorperazine Pediatric Dose?

Answer 8

Not recommended

Question 9

Prochlorperazine Onset of Action?

Answer 9

10-20 minutes

Question 10

Prochlorperazine Duration of Action?

Answer 10

4-12 hours

Question 11

Prochlorperazine Max Dose Adult/Pediatric?

Answer 11

40mg/day - Not recommended for peds.
*statpearls

Question 12

Prochlorperazine Routes of Administration?

Answer 12

IV/IO/IM

Question 13

Prochlorperazine How Supplied?

Answer 13

5mg/mL vials