Alteplase

Question 1

Alteplase Trade Name?

Answer 1

Activase

Question 2

Alteplase Classification?

Answer 2

Fibrinolytic-Thrombolytic Agent

Question 3

Alteplase Mechanism?

Answer 3

Binds to fibrin-bound plasminogen at the clot site to convert plasminogen to plasmin. Plasmin digests the fibrin strands of theclot.

Question 4

Alteplase Indications?

Answer 4

• Acute MI
• PE
• Ischemic stroke

Question 5

Alteplase Contraindications?

Answer 5

• Active internal bleeding
• Surgery within 2-3 weeks
• Previous CVA
• Prolonged CPR
• Brain or spinal surgery within 3 months
• Brain cancer
• Aneurysm
• Recent significant trauma, especially head trauma
• Uncontrolled hypertension (>185/110)

Question 6

Alteplase Side Effects/Precautions?

Answer 6

• Intracranial bleeding
• Headache
• Reperfusion dysrhythmias
• Chest pain
• GI bleeding
• Nausea/vomiting
• Abdominal pain
• Hypotension

Question 7

Alteplase Adult Dose?

Answer 7

0.9 mg/kg; first 10% administered over one minute; remaining 90% administered over 60 minutes

Question 8

Alteplase Pediatric Dose?

Answer 8

Not recommended

Question 9

Alteplase Onset of Action?

Answer 9

Variable

Question 10

Alteplase Duration of Action?

Answer 10

Clot lysis with 60-90 minutes

Question 11

Alteplase Max Dose Adult/Pediatric?

Answer 11

0.9mg/kg

Question 12

Alteplase Routes of Administration?

Answer 12

IV/IO

Question 13

Alteplase How Supplied?

Answer 13

50 mg and 100 mg powders that require reconstitution to a concentration of 1 mg/ml.