Plasmodium Flashcards
Malarial parasites name ??
- P vivax
- P ovale
- P falciparum
- P malariae
484
Recurrent fever pattern in malaria ??
- Recrudescence
- Relapse
487
Persistence of malarial parasites in blood in which erythrocytic forms are increased ?? —
Recrudescence
487
Persistence of hypnozoite form in the liver ??
Relapse stage
487
Benign tertian malaria which plasmodium ??
P vivax
488
Malignant tertian malaria plasmodium ??
P falciparum
488
Malaria agent ?
female anopheles
P malariae - type of malaria ?
quartan malaria
P ovale - type of malaria ?
ovale malaria
hilly area which P ?
falciparum
plain area which P >
P vivax – 484
vector & definative host of P >?
Female anopheles mosquito
sexual cycle is called ?
sporogony
what is produced in sporogny ?
sporozoites
asexual cycle called ?
schizogony
what produced in schizogny stage >
schizonts
asexual cycle occur where >
human
sexual cycle occur where ? mosquito
female
relapse fever pattern in which P ?
P ovale
P vivax
Recrudescence fever pattern in which P >
P falcciparum
P malariae
why P f & P m have no relapse ?
as they have no hypnozoite — no relapse
which forms persist in recrudescence ?
erythrocytic form
which form persist in relapse p[attern ?
hypnozoite stage
which stage commens again in relapse «
erythrocytic schizogny
why species differentiation is important?
as different species different Tx
Relapse M/A ?
487
Types of fever in malaria ?
tertian
quartan
quotidian
clinical features of malaria ?
chills
fever
anemia
splenomegaly
hallmark of malaria ?
paroxysm
stage of fever of malria ?
cold
hot
sweating/wet stage 489
transmission of malaria ?
489-490
sporozoites induced
trophozoite induced
-transfusion malaria
-congenital malaria
-malaria in drug addicts
therapeutic malaria
-emulsion of salivary gland containing sporozoites
-inoculating blood of an infected donor
-lab-bred infected mosquito bite
Microscopic examination of PBF By what ??
giemsa stained thick and thin blood flims
thick film Dx ?
presence of parasite
thin film Dx ?
confirm the Dx
identify species
quantify parasite load
how to quantify parasite load ?
by counting the % of infected erythrocytes
Gametocytes of P f shape ?
crescent / banana
other P - gametocytes shape ?
spherical
if > 5% RBC parasitized what is the Dx ?
P f
serologicAL test name
dipstcik test
/
ICT
/
immunochromatographic test
Blood count in Malaria ?
leucopenia
monocytosis
Anemia
No eosinophilia
special type protein released by P f?
histidine rich protein-2
HRP-2
Importance of HRP-2 ?
-identification of Falciparum
-monitoring Tx - after 2weeks of anti-malarial Tx - HRP-2 result ——
-non falciparum malaria = HRP-2 = (-)
when detecetion of malarial parasite in blood film is difficult ?
when taken from anti-malarial drug
in case of primary infection – (2-3) days
when blood films are taken during the apyrexial period of Pf
cerebral M te Pt complaint»_space;?
confusion
convulsion
coma
without localising signs
malaria hoy na in which genetic disease ?
G-6PD deficiency
why P f more severe ?
499
P f invade red cells of all ages
parasitemia is very high in Pf
H+N – cerebral M
occlusion of the capillaries
shows resistance to common anti-malarial drugs
what is Premunition ?
partial immunity based on humoral AB that block merozoites from invading the red cells occurs in infected individuals
disease caused by P f ??
malignant tertian malaria
pernicious M
black water fever
how to confirm D xof malaria ?
PBF
ICT
Cause of anemia in Malaria ?
-lysis of infecte dRBC - hemolysis
-immune mediated lysis of RBC - autoimmune hemolytic anemia
-splenomegaly - sequestration of RBC & lysis
-depletion of folic acid
-dyserthropoiesis
which drug cuase anemia in malaria ?
primaquine in G6PD d
P v VS P f ?/
488
distributions of P v in PBF ?
All stages
trophozoites
schizonts
gametocytes
distribution of P f in PBF ??
ONLY rings & crescents
- gametocytes
parasitized RBC features of P v?
fine stippling
schuffner dots
parasitized features of P f >
coarse stippling
maurers clefts
infective form of malaria ?
sporozoites
portal of entry of malria ><
skin
tertian fever hour ?
within 48hr cycle - fever recurs every third dY
72 hr cycle - recurs 4th day
quartan fever
ring stage trophozoites
pigements in trophozoites
older T in Pv ?
large
fine light brown
very pleomorphic ————– 488
chemoprophylaxis - in chloroquine resistance high ?
mefloquine
doxycycline
malarone
C resistance absent ??
C + proguanil = 300mg base weekly