Plasmodium Flashcards

1
Q

Malarial parasites name ??

A
  1. P vivax
  2. P ovale
  3. P falciparum
  4. P malariae

484

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2
Q

Recurrent fever pattern in malaria ??

A
  1. Recrudescence
  2. Relapse

487

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3
Q

Persistence of malarial parasites in blood in which erythrocytic forms are increased ?? —

A

Recrudescence

487

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4
Q

Persistence of hypnozoite form in the liver ??

A

Relapse stage

487

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5
Q

Benign tertian malaria which plasmodium ??

A

P vivax

488

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6
Q

Malignant tertian malaria plasmodium ??

A

P falciparum

488

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7
Q

Malaria agent ?

A

female anopheles

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7
Q

P malariae - type of malaria ?

A

quartan malaria

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8
Q

P ovale - type of malaria ?

A

ovale malaria

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9
Q

hilly area which P ?

A

falciparum

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10
Q

plain area which P >

A

P vivax – 484

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11
Q

vector & definative host of P >?

A

Female anopheles mosquito

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12
Q

sexual cycle is called ?

A

sporogony

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13
Q

what is produced in sporogny ?

A

sporozoites

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13
Q

asexual cycle called ?

A

schizogony

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14
Q

what produced in schizogny stage >

A

schizonts

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15
Q

asexual cycle occur where >

A

human

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16
Q

sexual cycle occur where ? mosquito

A

female

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17
Q

relapse fever pattern in which P ?

A

P ovale
P vivax

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18
Q

Recrudescence fever pattern in which P >

A

P falcciparum
P malariae

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19
Q

why P f & P m have no relapse ?

A

as they have no hypnozoite — no relapse

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20
Q

which forms persist in recrudescence ?

A

erythrocytic form

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21
Q

which form persist in relapse p[attern ?

A

hypnozoite stage

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22
Q

which stage commens again in relapse «

A

erythrocytic schizogny

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23
Q

why species differentiation is important?

A

as different species different Tx

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24
Q

Relapse M/A ?

25
Q

Types of fever in malaria ?

A

tertian
quartan
quotidian

26
Q

clinical features of malaria ?

A

chills
fever
anemia
splenomegaly

27
Q

hallmark of malaria ?

28
Q

stage of fever of malria ?

A

cold
hot
sweating/wet stage 489

29
Q

transmission of malaria ?

489-490

A

sporozoites induced
trophozoite induced
-transfusion malaria
-congenital malaria
-malaria in drug addicts
therapeutic malaria

-emulsion of salivary gland containing sporozoites
-inoculating blood of an infected donor
-lab-bred infected mosquito bite

30
Q

Microscopic examination of PBF By what ??

A

giemsa stained thick and thin blood flims

31
Q

thick film Dx ?

A

presence of parasite

32
Q

thin film Dx ?

A

confirm the Dx
identify species
quantify parasite load

33
Q

how to quantify parasite load ?

A

by counting the % of infected erythrocytes

34
Q

Gametocytes of P f shape ?

A

crescent / banana

35
Q

other P - gametocytes shape ?

36
Q

if > 5% RBC parasitized what is the Dx ?

37
Q

serologicAL test name

A

dipstcik test
/
ICT
/
immunochromatographic test

38
Q

Blood count in Malaria ?

A

leucopenia
monocytosis
Anemia
No eosinophilia

39
Q

special type protein released by P f?

A

histidine rich protein-2
HRP-2

40
Q

Importance of HRP-2 ?

A

-identification of Falciparum
-monitoring Tx - after 2weeks of anti-malarial Tx - HRP-2 result ——
-non falciparum malaria = HRP-2 = (-)

41
Q

when detecetion of malarial parasite in blood film is difficult ?

A

when taken from anti-malarial drug

in case of primary infection – (2-3) days

when blood films are taken during the apyrexial period of Pf

42
Q

cerebral M te Pt complaint&raquo_space;?

A

confusion
convulsion
coma
without localising signs

43
Q

malaria hoy na in which genetic disease ?

A

G-6PD deficiency

44
Q

why P f more severe ?
499

A

P f invade red cells of all ages

parasitemia is very high in Pf

H+N – cerebral M
occlusion of the capillaries

shows resistance to common anti-malarial drugs

45
Q

what is Premunition ?

A

partial immunity based on humoral AB that block merozoites from invading the red cells occurs in infected individuals

46
Q

disease caused by P f ??

A

malignant tertian malaria
pernicious M
black water fever

47
Q

how to confirm D xof malaria ?

48
Q

Cause of anemia in Malaria ?

A

-lysis of infecte dRBC - hemolysis
-immune mediated lysis of RBC - autoimmune hemolytic anemia

-splenomegaly - sequestration of RBC & lysis
-depletion of folic acid
-dyserthropoiesis

49
Q

which drug cuase anemia in malaria ?

A

primaquine in G6PD d

50
Q

P v VS P f ?/

51
Q

distributions of P v in PBF ?

A

All stages
trophozoites
schizonts
gametocytes

52
Q

distribution of P f in PBF ??

A

ONLY rings & crescents
- gametocytes

53
Q

parasitized RBC features of P v?

A

fine stippling
schuffner dots

54
Q

parasitized features of P f >

A

coarse stippling
maurers clefts

55
Q

infective form of malaria ?

A

sporozoites

56
Q

portal of entry of malria ><

57
Q

tertian fever hour ?

A

within 48hr cycle - fever recurs every third dY

58
Q

72 hr cycle - recurs 4th day

A

quartan fever

59
Q

ring stage trophozoites

pigements in trophozoites

older T in Pv ?

A

large

fine light brown

very pleomorphic ————– 488

60
Q

chemoprophylaxis - in chloroquine resistance high ?

A

mefloquine
doxycycline
malarone

61
Q

C resistance absent ??

A

C + proguanil = 300mg base weekly