Human Immunodeficiency Virus-HIV

Question 1

Sexual Transmission of HIV ?

Answer 1

1. Homosexual-Male common
2. Heterosexual

688

Question 2

Parental transmission of HIV ??

Answer 2

1. Blood & B products
2. Drug abusers
3. Contaminated needles

688

Question 2

Vertical transmission of HIV ??

Answer 2

1. During birth
2. Transplacental
3. Breast feeding

688

Question 3

Other method of HIV ??

Answer 3

1. Denoted organs
2. Denoted semen
3. Skin piercing
4. Sharping sharp razors

689

Question 4

why no vaccine of HIV ?

Answer 4

p24 - variation beshiiii

Question 5

HIV + HBV
konta age Tx ?

Answer 5

HBV

Question 6

HIV 1 vs HIV 2 = ??

Answer 6

HIV-1
worldwide
infectivity more
Incubation period - short
virulence - more

Question 6

Types of HIV ?

Answer 6

HIV - 1+2

Question 7

nucleocapsid core protein of HIV ?

Answer 7

p-24
p-17

Question 7

envelope Atg of HIV ?

Answer 7

gp-120
gp-41
enzyme atg-p53

Question 8

cancer associated with HIV ?

Answer 8

Non-hodgkin
kaposi sarcoma
burkitts lymphoma
cervical & anogenital cancer

Question 8

late / immunodeficiency phase CD4+ T cells count in HIV ?

Answer 8

&laquo_space;400 cells / micro L

Question 9

when opportunistic infection by HIV ?

Answer 9

CD4+ T cells &laquo_space;200 cells / micro L

Question 10

why persistant infection in HIV ?

Answer 10

integration of viral DNA into the DNA of infected cells

Question 11

regulatory genes in HIV required for replication ?

Answer 11

tat
rev

Question 12

stage of HIV ?

Answer 12

early/acute
middle latent
late/immunodeficiency

Question 13

tat function ?

Answer 13

activation of transport of viral genes

Question 14

rev function ?

Answer 14

transport of mRNA from Nucleus to cytoplasm

Question 15

sturctural genes found in retrovirus ?

Answer 15

gag
pol
env

Question 16

gag type ?

Answer 16

p24 p7
p17

Question 17

p17 of gag function ?

Answer 17

matrix

Question 18

p24 / p7 of gag fucntion ?

Answer 18

nucelocapsid

Question 19

env type >

Answer 19

Gp 120
Gp 41

Question 20

Gp 120 function ?

Answer 20

attachment of CD4 protein

Question 21

Gp 41 fucntion ?

Answer 21

fusion with host cells

Question 22

pol genes types ?

Answer 22

RT
protease
integrase

Question 23

Which suppression is marked in AIDS ?

Answer 23

CMI ==== Immunosuppressiomn

Question 24

acute stage of HIV infection time ?

Answer 24

2-4 weeks

Question 25

latent stage time ?

Answer 25

7-11 years

Question 26

seequestrated site of HIV during latent phase ?

Answer 26

lymph node

Question 27

why HIV more in female ?

Answer 27

viral load +++ beshi
sexual intercourse - microtrauma
larger mucosal surface
vaginal mucosa —- virus entry

Question 28

how CD4+ t cells are destryoed in AIDS ?

Answer 28

689

Question 29

anti-retroviral drugs name ?

Answer 29

zidovudine
etravirine

Question 30

HAART full form ?

Answer 30

highly active anti-retroviral therapy

Question 31

HAART drugs name ?

Answer 31

nucleoside /tide reverse transcriptase inhibitors +
one protease inhibitor

Question 32

combination therapy of HAART ?

Answer 32

NRTI + PI

/

NRTI + NNRTI 696

Question 33

How to monitor HIV ?

Answer 33

CD4+ T cell count
HIV RNA load
p24 Atg detection

Question 34

how to detect viral load ?

Answer 34

RT-PCR

Question 35

best & most consistent index for monitoring HIV ?

Answer 35

HIV RNA load

Question 36

opportunistic fungal infections by HIV ?

Answer 36

Candida
cryptococcus
coccidioides
histoplasma
pneumocystosis jiroveci

Question 37

Other protozoal infection ?

Answer 37

toxoplasma
strongyloides stercoralis

Question 38

serological test / detection of AB ?

Answer 38

ELISA
western blot

Question 39

detection of vrisal antigen >

Answer 39

p24 atg

Question 40

detetion of viral RNA process ?

Answer 40

PCR

Question 41

Immune function test ?

Answer 41

CD4+ cells &laquo_space;200/mm3

Question 42

why western blot not in use now ?

Answer 42

inability to detect acute infection
protential to misclassify HIV-2 infection as an HIV-1