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Microbiology -Medical-Prof > Clostridium > Flashcards

Clostridium Flashcards

1
Q

species of Clsotridium ??

A

C tetani
C perfringes
C botulinum
C difficile

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2
Q

Disease caused by Clostridium ??

A

C tetani - tetanus
C perfringes - Gas gangrene + food poisoning
C botulinum - botulism
C difficile - Pseudomembranous colitis

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3
Q

appearance of C tetani ?/

A

drumstick
/
tennis racket

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4
Q

toxin produced by it ??

A

T toxin
/
Tetanospasmin
/
neurotoxin

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5
Q

NON- characteristics of C t ??

A

NON-acid fast
NON-capsulated

201

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6
Q

Transmission of C t ??

A

Widespread in soil

201

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7
Q

Tetanus toxin to toxoid formation ??

A

lacks toxigenicity
but retain antigenecity of toxin and thus stimulates production of Anti-toxin

201

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8
Q

toxin name of C t ??

A

Tetanospasmin
Tetanolysin

202

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9
Q

M/A of tetanus ??

A

202

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10
Q

M/A of tetanus toxin ??

A

Bind with ganglioside receptor
block release of inhibitory NT - glycine & GABA
No inhibition of LMN by UMN
Exaggerated action of LMN

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11
Q

Result of Tetanus ??

A

Inc muscle tone
spastic paralysis
hyper-excitability of voluntary muscles

202

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12
Q

Can Dx of tetanus made from Culture/media ?/

A

No
its clinical

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13
Q

Clinical Dx of tetanus ??

A

lockJaw- trismus
risus sardonicus
OpisthoTones
exaggerated reflexs

203

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14
Q

Pre-exposure prevention / immunization of T ?

A

TT
EPI schedule
6-10-14 weeks
booster - every 10 years

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15
Q

Pregnant women vaccine for tetanus ?/

A

5 doses of TT vaccine

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16
Q

Post-exposure prophylaxis ?/

A

passive immunization
TIG
250-500 units in IM

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17
Q

Which Antibiotics for tetanus ??

A

Benzodiazepine
to prevent spasm
Benzyl Penicillin - 600mg IV 6hourly
Metronidazole

18
Q

what type of immunity in tetanus ??

A

active-passive immunity

204

19
Q

Canned food / vacuum packed food contamination in which C ??

A

C botulinum

20
Q

which type of paralysis by C botulinum ??

A

flaccid paralysis

21
Q

Mechanism of Toxicity ??

A

Botulinum toxin = block release of Ach = Blockage of synaptic Ach release = Flaccid paralysis

206

22
Q

Commercial preparation of exotoxin A of C botulinum ??

23
Q

uses of Botox ??

A
  • removal wrinkles of face - osmotic reduction
  • Tx of - torticollis + writers cramp + blepharospasm

206

24
Q

clinical features of Botulism ??

A
  • Descending paralysis
    visual disturbance - double vision
    speech dificulty
25
Q

types of Botulism ??

A
  1. food borne
    wound
    infant
    unclassifies
26
Q

Infant botulism complication ??

A

Floppy baby syndrome

27
Q

why Botulism not a classical example of food poisoning ??

A

NO V -D
no action on GIT

207

28
Q

Bacteria causing Food poisoning ??

A

208
Escherichia coli

13-2-2025
6.03

29
Q

Feature of botulism - 5D ??

A

Diplopia
dysarthria
dysphagia
dyspnea
dysending flaccid paralysis

207

30
Q

Culture for food poisoning ??

31
Q

Disease caused by C perfringens ??

A

Gas gangrene
Anaerobic cellulitis
Food poisoning

32
Q

Gas gangrene other name ??

A

Myonecrosis

33
Q

Toxins type in myonecrosis ??

A

alpha / lecithinase
theta

34
Q

theta toxin effect - hemolytic & necrotizing effects

35
Q

alpha toxin effects ??

A

degrade lecithin

36
Q

How to identify alpha toxin by cultire ?/

A

egg yolk agar

37
Q

Culutre media for C perfringes ?/

A

Robertsons cooked meat media
thioglycolate media
egg yolk media

38
Q

Pathogenesis of gas gangrene / myonecrosis ??

39
Q

Prevention & control of GG ??

40
Q

Predisposing fators of Pseudomembranous colitis by C difficile ??

A

clindamycin
ampicillin
2 & 3 Generation of cephalosporins
fluroquinolones
cancer chemotherapy

212

41
Q

50 years male + severe diarrhea + UTI
??/

A

C difficile

42
Q

nosocomial cause of diarhea ??

A

C difficile

212

14-2-2025
2.51PM

Microbiology -Medical-Prof (49 decks)

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