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Microbiology -Medical > Immunity-Autoimmunity > Flashcards

Immunity-Autoimmunity Flashcards

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USMLE® Step 1 flashcards Biology 101 flashcards
1
Q

Autoimmunity definition ??

A

Immune response against self antigens due to loss of self tolerance in B & T cells or both

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2
Q

Autoimmune disease ?? Def

A

The D caused by autoimmunity are referred to as AID

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3
Q

Pernicious anemia organ ??

A

Gastric parietal cell

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3
Q

Hashimotos thyroiditis organ ??

A

Thyroid gland

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3
Q

Myasthenia gravis D organ >??

A

Muscle

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4
Q

e

Autoimmune haemolytic anemia organ ??

A

Erythrocytes

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4
Q

Idiopathic thrombocytopenic purpura organ ??

A

Platelets

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5
Q

SLE organ ??

A

Multi system

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6
Q

Rheumatic fever organ ??

A

Joints & heart valves

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7
Q

Rheumatoid arthritis organ ??

A

Joints and organs

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8
Q

Mechanism of autoimmunity 4 point ??

A
  1. Molecular mimicry
    2.Epitope spreading
    3.Failure of Treg
    4.NeoAntigens

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9
Q

Molecular mimicry - Tell in your own word ??

A
  1. AA sequence of Self Atg = AA sequence of Microbes Atg
  2. Immune response against microbes Atg
  3. Activation of self reactive lymphocytes

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10
Q

Example of Molecular mimicry ??

A
  1. GBS
  2. Reiters syndrome
  3. Rheumatic heart D

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11
Q

Reiters syndrome microbes ??

A
  1. Shigella
  2. Chlamydia

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12
Q

Guillain Barre syndrome microbes ??

A
  1. Campylobacter

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13
Q

RHD mecha ?/

A

AB againts streptococcus M protein cross react with myocardial protein

14
Q

End result of RHD ??

A

Myocarditis

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15
Q

Myasthenia gravis D receptor associated with ??

A

Ach receptor

16
Q

Graves disease receptor ?/

A

TSH r

17
Q

Rheumatoid arthritis R ??

A

IgG in joints

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18
Q

Goodpostures syndrome ??

A

Basement membrane of kidney & lung

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19
Q

SLE r ??

A

dsDNA & Histone

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20
Q

Epitope spreading mecha in your own word ??

A
  1. Damage to cells
  2. Damage caused by - Viral bacterial infections
  3. New exposure of sequestered autoAtg

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21
Q

D associated with ES ??

A
  1. SLE
  2. MS
  3. Pemphigus vulgaris
  4. IBD
  5. Crohns D
  6. Ulcerative colitis

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22
Q

Failure of Treg cell outcome ??

A

Treg cell = Suppress proinflammtory effects
So inflammation associated D occure

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23
Q

D associated with failure of Treg cells ??

A
  1. SLE
24
Q

Neoantigens who ????

A

SelfAtg that have been modified by some extrinsic factors so that they appear foreign to immune system

25
Q

D associated with Neo Atg ??

A

Procainamide induced SLE

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26
Q

R fever microbes ??

A

Streptococcus pyogens

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27
Q

R arthritis microbes ??

A

Yersinia enterocolitica

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A
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29
Q
A

Microbiology -Medical (29 decks)

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