Plasma Cell Dyscrasias Flashcards
What is multiple myeloma?
Primary bone neoplasm of WBC in older individuals
With multiple myeloma, malignant plasma cells secrete…
antibody: myeloma protein or “M” spike
What is Bence-Jones protein?
Ig light chain; massive protein urea
Found in multiple myeloma
What is the skeletal involvement in multiple myeloma?
Vertebrae, skull, long bones
What is the role of cytokines (OAFs) in multiple myeloma?
Plasma cell proliferation and osteoclast activity
Normally, there is ___ albumin than antibodies
more
What is the most prominent blood protein?
Albumin
The “M” spike is caused by an abnormal level of…
IgG
What is Waldenstroms macroglobulinemia (in comparison to multiple myeloma)?
Proliferation of variable number of IGM secreting plasma cells
What is the clinical presentation of multiple myeloma?
- Hypercalcemia
- Systemic infection
- Renal disease
- Pathologic fractures
What type of damage to the skull is caused by multiple myeloma?
Punched out lesions in the skull
