Basic Terms/Concepts Flashcards
Name the “seven pillars”; the aspects of a disease that form the core of pathology
- Etiology
- Pathogenesis
- Manifestation
- Progression
- Diagnosis
- Treatment
- Prognosis
What is etiology?
Cause of pathology
What is pathogenesis?
“Dominos” leading to pathology occurring before diagnosis
What is manifestation?
Pathology has been or can reasonably be diagnosed
What is progression?
The course of the disease as it worsens or spreads
What is prophylactic treatment?
Preventative treatment
What is proper treatment?
Treatment occurs after symptoms present
What is prognosis?
Likely outcome of disease
What does it mean if a symptom is focal?
Location is known and well circumscribed
What does it mean if a symptom is diffuse?
Unclear where symptom starts and ends
Microscopic tissues can be seen by…
Macroscopic tissues can be seen by…
microscopic: microscope
macroscopic: naked eye
How does an eosinophilic tissue appear with H&E staining?
Absent nucleus; necrotic (dying)
How does a basophilic tissue appear with H&E staining?
Large nucleus; dividing
If something is endogenous, where does it come from?
And if exogenous?
endogenous: from within
exogenous: from exterior
What is morbidity?
Refers to illness
What is mortality?
Refers to death
What is co-morbidity?
State of more than one disease
In response to a stimulus, cells undergo changes including…
- cellular adaptation
- reversible cell injury
Note: irreversible cell injury is cell death
The potential for regeneration refers to what ability of the cell?
Division
Describe labile cells with examples
They continuously renew their cell population
ex. skin, anything epithelial
Describe stable cells with examples
They potentially expand their cell population
ex. osteoblast, chondroblast, stem cells, hepatocytes
Describe permanent cells with examples
Cell population is static
ex. striated muscle, CNS neurons
The ability of a tissue or organ to adapt to an injury/stress is dictated by what six factors?
- Potential for regeneration
- Severity of the injury
- Duration of the injury
- Condition of the cell
- Location of the cell
- Degree of cell specialization
