Phases of Wound Healing and Aberrant Wound Healing

Question 1

There are ___ phases of wound healing. The ____ or coagulation phase occurs immediately ___ injury with the result of a __________________. The inflammatory phase follows the ____ phase which is followed in turn by the _____ and then the ____ phases.

Answer 1

There are 4 phases of wound healing. The haemostatic or coagulation phase occurs immediately after injury with the result of a clot formation and the cessation of bleeding. The inflammatory phase follows the haemostatic phase which is followed in turn by the proliferative and then the remodelling phases.

Question 2

shortest wound healing phase

Answer 2

first phase: has the platelet as the main cell involvement and lasts the shortest amount of time

Question 3

following the hemostasis phase, there is ____ and ___ recruitment as the wound moves into the ____ phase, which lasts a few days. this phase removes ____, ___ ____ and sets the stage for formation of the new tissue.

Answer 3

following the hemostasis phase, there is NEUTROPHIL and MACROPHAGE recruitment as the wound moves into the INFLAMMATORY phase, which lasts a few days. this phase removes BACTERIA, NECROTIC TISSYE, and sets the stage for formation of the new tissue.

Question 4

In the proliferative stage the ____ is the main player, laying down new ____ and extracellular matrix as well as forming new ___ ____. Clinically we see this as ____ tissue. This phase lasts days. Re-____ of the wound occurs at the end of the proliferative phase.

Answer 4

In the proliferative stage the fibroblast is the main player, laying down new collagen and extracellular matrix as well as forming new blood vessels. Clinically we see this as granulation tissue. This phase lasts days. Re-epithelialization of the wound occurs at the end of the proliferative phase.

Question 5

Chronic wounds get stuck between the _____ and the next phase in a normal wound healing trajectory, the ____ phase

Answer 5

Chronic wounds get stuck between the inflammatory and the next phase in a normal wound healing trajectory, the proliferative phase

Question 6

in the remodelling phase, which can last years, the ___ has a major role. the best possible result of wound healing is a scar which has only ____% of the tensile strength of original skin.

Answer 6

in the remodelling phase, which can last years, the FIBROBLAST has a major role. the best possible result of wound healing is a scar which has only 75% of the tensile strength of original skin.

Question 7

what stage of healing is thsi scar in?

Answer 7

the white portions indicate granulocyte involvement, indicating proliferative stage.

Question 8

when is a wound considered to be chronic?

Answer 8

6 weeks post wounding

Question 10

both keloids and hypertrophic scars have ____ involvement with excess ___ production in repsonse to an injury to the skin.

Answer 10

both keloids and hypertrophic scars have FIBROBLAST involvement with excess COLLAGEN production in repsonse to an injury to the skin.

Question 11

factors that affect keloid formation (5)

Answer 11

1. genes
2. depth, type and location of injury
3. degree of tension across the wound surface
4. presence of local infection
5. hormonal influences.

Question 12

hypertrophic or keloid?

Answer 12

keloid

Question 13

what type of aberrane scar is most common?

Answer 13

hypertrophic. they are raised, confined tot he wound margins and sometimes improves spontaneously.

Question 14

which type of scar has a better response to treatment : keloids or hypertropic scares?

Answer 14

hypertrophic.

Keloids tend to extend beyond the original wound margins, are typically delayed in onset, seldom resolve spontaneously and their response to treatment is often poor