Drug Eruptions

Question 1

describe the morphology and specific type of rash

Answer 1

erythematous papules coalescing into large plaques. possibly edematous. well defined borders. this is a MORBILIFORM eruption, considered a maculopapular drug eruption

Question 2

when are you most likely to see a maculopapular drug eruption

Answer 2

The cutaneous eruption classically begins 7 to 14 days after the start of a new medication and can even occur a few days after the drug has been discontinued. . it’s often because a cell-mediated hypersensitivity reaction, Pruritus is the major complaint from most patients

Question 3

type of rash

Answer 3

morbiliform rash that is indicative of maculopapular drug eruption

Question 4

drug causes of TEN or SJS

Answer 4

allopurinol, NSAIDs, antibiotics, anticonvulsants.

Question 5

Answer 5

Toxic epidermal necrolysis. covers more than 30% body surface area. optimal medical managemnet requires early disagnosis, immediate discontinuiation of causative drugs and rapid initiaition of supportice care and specific therapy.

Question 6

severe forms of maculopapular drug eruptions

Answer 6

peripheral eosinophilia, renal or hepatix dysfunction– DRESS: drug reaction with eosinophilia and systemic symptoms

Question 8

what drugs cause this reaciton?

Answer 8

erythema nodosum; specific estrogens and oral contraceptive pills, sulfonamides, bromides, penicillin, iodides and TNF inhibitors.

Question 9

erythema nodosum is usually distributed symmetrically over ____ areas; occasionally elsewhere. In later stages, lesions acquire a ___-like appearance. May be accompanied by ___, ___ and malaise

Answer 9

Usually distributed symmetrically over pretibial areas; occasionally elsewhere. In later stages, lesions acquire a bruise-like appearance. May be accompanied by fever, arthralgias and malaise