Pathology - Neoplastic Disorders

Question 1

what karyotypic abnormality is associated with synovial sarcoma?

Answer 1

t(X;18)

Question 2

what karyotypic abnormality is associated with alveolar rhabdomyosarcoma?

Answer 2

t(2;13)

Question 3

what karyotypic abnormality is associated with ewing’s sarcoma?

Answer 3

t(11;22)

Question 4

where are ganglion cysts usually located?

Answer 4

peripherally
near a joint capsule or tendon sheath

commonly around the wrist

Question 5

what is the pathophysiology behind ganglion cysts?

Answer 5

degenerative changes within connective tissue

Question 6

are ganglion cysts true cysts?

Answer 6

no - as they have no epithelial lining

Question 7

describe the histological appearance of ganglion cysts

Answer 7

a space filled with myxoid material

Question 8

who is most commonly affected by dupuytren’s?

Answer 8

males

aveage age = 60

Question 9

what causes dupuytren’s?

Answer 9

it is idiopathic

associated with alcohol, DM and anti-convulsants

Question 10

what is a penile superficial fibromatoses called?

Answer 10

peyronie’s disease

Question 11

what body parts can be affected by deep fibromatosis?

Answer 11

mesentery

pelvic cavity

Question 12

what syndrome is associated with deep fibromatosis?

Answer 12

familial adenomatous polyposis

Question 13

describe the microscopic appearance of lipoma

Answer 13

resembles normal fat
white
nuclei small, at the edge of cells

Question 14

are rhabdomyomas benign or malignant?

Answer 14

benign

Question 15

what syndromes can be associated with enchondroma?

Answer 15

ollier’s

maffuci