P5 PHARMACOLOGY

Question 1

therapy of IBD depends on the

Answer 1

severity of the disease

Question 2

incase of mild severity your chosen therapy is

Answer 2

topical corticosteroids
5-Aminosalicylates

Question 3

incase of moderate severity your chosen therapy is

Answer 3

oral corticosteroids
immuno-modulaters

Question 4

incase if severe IBD your chosen therapy is

Answer 4

Intravenous corticosteroids
cyclosporine / surgery

Question 5

MOA of Aminosalicylates

Answer 5

anti-inflammatory , blocking prostaglandins /cytokines / T cell function

Question 6

reason behind Aminosalicylates not reaching colon

Answer 6

getting absorbed from small intestines

Question 7

5-ASA are bound with sulfasalazine due to the presence of what bond

Answer 7

azo bond

Question 8

Examples of other 2 drugs containing azo bound

Answer 8

balsalazide , olsalazine

Question 9

azo bound will help in increasing

Answer 9

Resistance of 5-ASA to small intestines degradation

Question 10

Component in sulfasalazine that causes its side effects

Answer 10

sulfapyridine

Question 11

side effects of sulfasalazine

Answer 11

angioedema , hepatotoxicity

Question 12

other routes of administration for 5-ASA

Answer 12

• Enema -Suppository - Foam

Question 13

incase of proctitis & sigmoid inflammation
what is your chosen route to administer 5-ASA

Answer 13

foam

Question 14

incase of ONLY proctitis , what is your chosen route to administer 5-ASA

Answer 14

Suppository

Question 15

incase of descending colon inflammation , your chosen route to administer 5-ASA

Answer 15

Enema

Question 16

Formulations of topical corticosteroids

Answer 16

foam , enema , suppository

Question 17

drugs available as topical corticosteroids

Answer 17

Hydrocortisone & budesonide

Question 18

drugs available to be used intravenously corticosteroids

Answer 18

Hydrocortisone & methylprednissolone

Question 19

you can use iv corticosteroids only for

Answer 19

1-7 days ( 1-2 days )

Question 20

ADR of IV corticosteroids

Answer 20

acute fulminant colitis

Question 21

Drugs available as oral corticosteroids

Answer 21

Prednisone & prednisolone & budesonide

Question 22

if you suddenly stopped oral corticosteroids the patient will develop

Answer 22

adrenal insufficiency

Question 23

course of treatment with oral corticosteroids

Answer 23

1-2 weeks

Question 24

upon using immuno-modulators & biologics , patients might develop TB or secondary malignancies , this is due to

Answer 24

CD8 suppression

Question 25

Indication to use immuno-modulators / biologics

Answer 25

Recurrence / no response to conventional drugs

Question 26

incase of amebic dysentery in lumen , your chosen drug is

Answer 26

luminal amebicide

Question 27

when the amoeba is in the extra-intestinal tissues , your chosen drug is

Answer 27

tissue amebicide

Question 28

Examples of tissue amebicide

Answer 28

Metronidazole , tinidazole , secnidazole , chloroquine

Question 29

Metronidazole is used in

Answer 29

extra-intestinal amebiasis , liver & brain abscess

Question 30

Microorganisms that can be killed by metronidazole

Answer 30

• H. pylori
• Entamoeba histolytica
• Trichomonas vaginalis
• Giardia lamblia

Question 31

MOA of metronidazole

Answer 31

Interferes with DNA synthesis

Question 32

Contraindication for metronidazole

Answer 32

first trimester pregnancy

Question 33

you will alert the patient that they will sense a change in

Answer 33

taste sensation , will have metallic taste

Question 34

uses of luminal amebicide

Answer 34

carriers /asymptomatic infections & amoebic dysenteries & following tissue amebicide

Question 35

Examples of luminal amebicides

Answer 35

paramomycin , Iodoquinol , diloxanide furoate