P2 PHARAMCOLOGY

Question 1

drugs that act by neutralising gastric acid secretion

Answer 1

Antacids

Question 2

drugs that act by reducing gastric acid production

Answer 2

1-H2 receptor blocker
2-Prostaglandins analogues
3-PPIs

Question 3

antacids that can cause metabolic alkalosis

Answer 3

NaHCO3
CaCO3

Question 4

NaHCO3 & CaCO3 causes metabolic alkalosis due to

Answer 4

Their faster reaction

Question 5

antacids that are commonly used

Answer 5

AI(OH)3
Mg(OH)2

Question 6

side effect of magnesium in antacids

Answer 6

Diarrhea

Question 7

side effect of aluminium in antacids

Answer 7

constipation

Question 8

drug interactions for antacids

Answer 8

NOT to take any other drug within 2 hours

Question 9

side effects of NaHCO3 & CaCO3

Answer 9

Metabolic alkalosis
Abdominal bloating sensation

Question 10

Cimetidine , ranitidine
famotidine , nizatidine
are all examples of which drug classes

Answer 10

H2 receptor antagonists / blocker

Question 11

ADR of cimetidine

Answer 11

Gynecomastia
Impotence
galactorrhea
CYP inhibition

Question 12

mechanism of cimetidine causing Gynecomastia & galactorrhea

Answer 12

Interferes with prolactin & estradiol

Question 13

DOC from H2 receptor antagonists

Answer 13

Ranitidine

Question 14

Instructions for ranitidine

Answer 14

IV slow bolus

Question 15

name drugs acting by inhibiting proton pumps

Answer 15

omeprazole , Esomeprazole
Lansoprazole
dexlansoprazole
pantoprazole

Question 16

MOA of PPIs

Answer 16

Irreversible inhibition of proton pump

Question 17

Indication for PPIs

Answer 17

1-GERD
2-PEPTIC ULCER
3-stress induced peptic ulcer

Question 18

ADR of PPIs

Answer 18

1-Kidney disease ( nephritis)
2-osteoporosis
3- B12 deficiency

Question 19

Drug interactions with PPIs

Answer 19

with clopidogrel

Question 20

in triple therapy drugs are

Answer 20

1 PPI
2 antimicrobial

Question 21

if the patient has resistance to Clarithromycin switch for

Answer 21

Quadruple therapy

Question 22

duration of H.pylori regimen

Answer 22

14 days / 2 weeks

Question 23

PPI should be continued for

Answer 23

4 to 6 weeks after stopping antimicrobials

Question 24

MOA Prostaglandin analogous

Answer 24

enhance protection by inhibiting proton pump

Question 25

indications for prostaglandin analogues

Answer 25

NSAIDs induced ulcers

Question 26

Contraindications for prostaglandin analogous

Answer 26

Pregnancy > abortion

Question 27

MOA of sucralfate

Answer 27

- physical barrier - stimulate HCO3 & PG production

Question 28

indications for sucralfate

Answer 28

stress induced ulcers

Question 29

MOA of bismuth

Answer 29

Direct antimicrobial effect

Question 30

uses for bismuth

Answer 30

for quadruple therapy

Question 31

Patients on drug therapy containing bismuth can complain of

Answer 31

black stool which will return to normal