P5 IMMUNOLOGY Flashcards
Immunoglobulin that has an important role in GI
IgA
deifne GALT
Gut associated lymphoid tissue
Protein present on helper T cells
CD4
protein present on cytotoxic / killer T cells
CD8
GALT is composed of what cells
lymphoid + myeloid cells
non-immune protection of intestinal mucosa
gastric acid
microflora
proteolytic enzymes
Physical barrier
limb that gathers information on antigens
Afferent limb
limb that gives a response for antigens
efferent limb
Afferent limb is located in
aggregated lymphoid tissue
efferent limb is located in
diffuse lymphoid tissue
cells of GALT are located between
Intestinal lumen
& serosa of intestine
in GALT , lymphocytes migrate from
Peyer’s patches
Through which lymph node do lymphocytes migrate
Through mesenteric
lymph nodes & thoracic duct
has the role of antigen transportation
M cells
Major function of IgA
Neutralises viruses , bacteria & toxins
IgA is referred to as
mucosal antiseptic paint
in response to parasites & allergy , which immunoglobulin will give response
IgE
T-cells immune response is in common in
Protozoal infection , AIDS
gluten enteropathy , IBD
graft versus host reaction
Systemic hyporesponsiveness to orally ingested antigens
tolerance
Immediate hypersensitivity type 1/2 mediated by cellular activity
Hypersensitivity
Genetic predisposition in Crohn’s is in
HLA-DR1
T -cells in Crohn’s
T helper 1
Interleukin in Crohn’s
IL-12
Genetic predisposition in ulcerative colitis is in
HLA-DR2
