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UNIT 5 GI > P1 PHARMACOLOGY > Flashcards

P1 PHARMACOLOGY Flashcards

1
Q

drugs that enhance motility of GI

A

prokinetic drugs

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2
Q

type of motility aiming for

A

Coordinated GI motility

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3
Q

main 2 drugs of choice

A

metoclopramide & domperidone

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4
Q

effector neuron proximal to bolus release

A

ACH

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5
Q

effector neuron distal to bolus

A

nitric oxide , vasoactive intestinal polypeptide

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6
Q

ACH secretion causes

A

Contraction of the muscle

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7
Q

NO & VIP causes

A

Relaxation of the muscle

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8
Q

cholinergic drugs are not used anymore due to

A

Unspecific to GI muscarinic receptors
Uncoordinated GI motility

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9
Q

Example s on cholinergic drugs

A

bethanechol
neostigmine

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10
Q

MOA of bethanechol

A

acting on M3 receptors directly

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11
Q

MOA of neostigmine

A

Reversible Ach esterase inhibitor
indirectly

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12
Q

cholinergic agonists are used nowadays rarely for

A

post - operative paralytic ileus

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13
Q

MOA of Domperidone

A

D2 - antagonist

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14
Q

Effects of domperidone

A

1- ↑LES tone
2- Facilitate peristalsis and gastric emptying
3- Relaxation of pyloric antrum & 1st part of duodenum
4-↑ prolactin levels
5- anti-emetic

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15
Q

Indications for domperidone

A

GERD / diabetic gastroparesis / lactational deficiency / anti-emetic

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16
Q

ADR of domperidone

A

hyperprolactinemia

17
Q

MOA of metoclopramide

A

D2- antagonist
5HT3- antagonist
5HT4- agonist

18
Q

effects of metoclopramide

A

1- ↑LES tone
2- Facilitate peristalsis and gastric emptying
3- Relaxation of pyloric antrum & 1st part of duodenum
4-↑ prolactin levels
5- anti-emetic

19
Q

indications for metoclopramide

A

GERD / diabetic gastroparesis / lactational deficiency / anti-emetic

20
Q

ADR of metoclopramide

A

hyperprolactinemia / induced Parkinsonism

21
Q

why do metoclopramide induce Parkinson disease

A

it crosses BBB

22
Q

What is your DRUG OF CHOICE from dopamine receptor antagonists

A

Domperidone

23
Q

drugs used to facilitate colon movement

A

prucalopride

24
Q

to what drug classes does prucalopride belongs to

A

serotonin receptor agonist

25
Q

MOA of prucalopride

A

acting as 5HT-4 agonist

26
Q

serotonin agonist drugs are used for

A

Idiopathic constipation

27
Q

ADR of prucalopride

A

headache
nausea
vomiting

28
Q

drugs that are no longer used due to resistance

A

motilides / macrolides

29
Q

name the drug belonging to macrolides

A

Erythromycin

30
Q

MOA of erythromycin

A

motilin receptor agonist

31
Q

Housekeeper of the gut

A

motilin

32
Q

macrolides were used for

A

Improve peristalsis in small intestine

33
Q

Your DRUGS OF CHOICE in case of achalasia cardia

A

CCBs / organic nitrates / botulinum toxin

34
Q

Example for CCB

A

nifedipine

35
Q

Example for organic nitrate

A

isosorbide dinitrate

36
Q

Botulinum toxin is produced from

A

Clostridium botulinum ( bacteria )

37
Q

MOA of botulinum toxin

A

blocks stimulus-induced ACH release

UNIT 5 GI (34 decks)

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