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UNIT 5 GI > P3 MICROBIOLOGY > Flashcards

P3 MICROBIOLOGY Flashcards

1
Q

infections caused by agents whose primary tissue tropism is the liver

A

viral hepatitis

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1
Q

most common hepatitis viruses

A

Hepatitis A,B,C,D,E

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2
Q

other hepatitis viruses to be excluded

A

CMV , Epstein - barr virus , herpes simplex virus
Yellow fever , rubella

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3
Q

enterically transmitted hepatitis

A

A ,E

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4
Q

Parenterally transmitted hepatitis

A

B , C , D

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5
Q

genome in hepatitis A

A

simple stranded RNA

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6
Q

Characteristics of hepatitis A virus

A

picornavirus , enterovirus 72
small , non-enveloped icoshedral particle

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7
Q

Transmission of hepatitis A virus

A

Contaminated food & water

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8
Q

Incubation period for hepatitis A virus

A

3-5 weeks

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9
Q

Hepatitis A cells multiplies in

A

liver cells

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10
Q

Hepatitis A infected patients have the risk to spread the disease due to

A

its excretion in the stools for 2 weeks

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11
Q

Hepatitis A is more severe in

A

Pregnant patients

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12
Q

Complications of hepatitis A

A

Fulminant hepatitis

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13
Q

Transmission of hepatitis A is always linked with

A

linked with hygiene

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14
Q

Transmission of hepatitis A

A

via fecal-oral route

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15
Q

to diagnose patient is now having hepatitis A you need to measure

A

IgM levels

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16
Q

to prove that the patient had an infection with hepatitis A you need to measure

A

IgG

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17
Q

if the patient is vaccinated their serum will show

A

IgG

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18
Q

Prevention from hepatitis A

A

passive / active immunisation

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19
Q

hepatitis E family

A

calicivirus

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20
Q

Hepatitis E virus characteristics

A

Spherical , non-enveloped

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21
Q

genome in hepatitis E virus

A

single stranded RNA

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22
Q

Incubation period for hepatitis E

A

30-40 days

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23
Q

age group infected by Hepatitis E

A

young adults , 15 - 40 years

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24
Complications of hepatitis E
fulminant hepatitis in pregnant women
25
Transmission of hepatitis E
via contaminated water & food
26
Diagnosis of hepatitis E is taken from what specimen
stool , serum (blood)
27
in stool specimen for hepatitis E you will detect
calicivirus like particles HEV specific sequences
28
best rapid way to diagnose hepatitis E
serum IgM
29
genome in hepatitis B
circular double stranded DNA
30
HBV antigens
HBsAg , HBsAg , HBeAg
31
protein of HBsAg is a
surface / coat protein
32
Protein of HBcAg is a
inner core protein
33
Protein of HBeAg is a
Secreted protein / replication protein
34
types of Transmission in hepatitis B
vertical , sexual
35
a mother can transmit hepatitis B to the baby by
transplacental , during delivery , post-natal
36
incubation period for hepatitis B
2-5 months
37
Complications of hepatitis B infection
Persistent infection Fulminant hepatitis
38
groups at risk for hepatitis B
young children / babies immunocompromised patients
39
gender at more risk for hepatitis B
males
40
best antigen to diagnose hepatitis B
HBs Ag
41
what antibody is the only detectable in the window period
IgM anti-core HBc-IgM
42
Chronic hepatitis B infection patients are at highly risk of developing
hepatocellular carcinoma
43
which one of the hepatitis viruses is linked/ dependent on hepatitis B
Hepatitis D
44
Hepatitis B helps hepatitis D with its
replication
45
genome in hepatitis D
single stranded RNA
46
Clinical features of hepatitis D infection
Increased severity in HBV carriers
47
Hepatitis D is present more in
intra-venous drug abusers ( Italy )
48
genome in hepatitis C
single stranded RNA
49
incubation of hepatitis C
6-8 weeks
50
Complications in hepatitis C
Chronic liver disease hepatocellular carcinoma
51
Transmission of hepatitis C
blood transfusions organ donation IV abuse Sexual intercourse
52
tests to diagnose hepatitis C
Serology RT-PCR
53
RT-PCR will detect
viral load Genotype
54
in serology you will detect
IgG
55
HCV genotype 1,2,3 are present in
Worldwide
56
HCV genotype 4 is found in
middle east , Egypt central africa
57
HCV genotype 5 is present in
south africa
58
high mortality rate in pregnant women
Hepatitis E virus
59
markers specific to immunity to HBV
anti-HBs
60
major route for hepatitis A virus
fecal-oral route
61
Interferons function
alert neighbouring cells of the infected cells to be in the antiviral state

UNIT 5 GI (34 decks)

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