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UNIT 5 GI > P2 MICROBIOLOGY > Flashcards

P2 MICROBIOLOGY Flashcards

1
Q

Campylobacter like organisms

A

Helicobacter pylori

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2
Q

shape of H.pylori

A

spiral shaped

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3
Q

H.PYLORI causes

A

Gastritis , peptic ulcer, stomach cancer , MALT

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4
Q

Characteristics of H.pylori

A

gram negative
spiral shaped
Highly motile with lopotrichus flagella
microaerophilic
urease +

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5
Q

what dose microaerophilic

A

Require little CO2

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6
Q

meaning of urease +

A

converts urea to ammonia
produces urea as well

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7
Q

Transmission of H.pylori

A

oral-oral
oral-fecal

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8
Q

what is a microaerophilic environment

A

5% O2 , 10% CO2 , 85% N2

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9
Q

Virulence factors in H.PYLORI

A

1-flagella
2-urease
3-toxins
4-adhesins
5-enzymes /lipopolysaccharides

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10
Q

ROLE OF flagella

A

Motility in mucus layer

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11
Q

role of urease

A

breakdown of urea into CO2 & ammonia
= neutralise acid

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12
Q

role of lipopolysaccharides

A

adhesion + damage to host cell

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13
Q

role of adhesions

A

hemagglutinins , sialic acid binding

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14
Q

role of CagA gene

A

remodel host cell , inhibit apoptosis
Production of IL-8

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15
Q

what cytokines increases gastrin release

A

TNF-ALPHA
IL-8
INF-1GAMMA `

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16
Q

TNF-ALPHA lowers D cells causing

A

to lower somatostatin levels

17
Q

major location of H.pylori infection

A

antrum of the stomach
proximal , distal duodenum

18
Q

Mention difference’s between H.pylori & Campylobacter

A

H.pylori : 1- multiple flagella
2- urease +
Campylobacter :1- single flagella
2- urease -

19
Q

Invasive diagnosis tests done

A

rapid urease
direct microscopy
Histology , culture

20
Q

non-invasive diagnosis tests done

A

urea breath test , IgG / IgA immunoglobulins , PCR , antigens in stool

21
Q

in CLO test we are looking for colour change form

A

Yellow to red/magneta

22
Q

Yellow to red change in color indicates

A

Urease is present

23
Q

in culture , what agars do we prefer

A

skirrow/dent agars
blood / chocolate agars

24
Q

blood / chocolate agars are what type of agars

A

non selective

25
Q

Selective type of agar

A

dent’s / skirrow’s

26
Q

Biochemical properties of H.pylori

A

urease+
Catalase +
Oxidase +

27
Q

+ Ag detection in stool shows

A

1 blue & 1 pink / red lines

28
Q

in what test you will check for color change if the IgA / IgM is present

A

ELISA

29
Q

in urea breath test you are detecting

A

13 carbon

UNIT 5 GI (34 decks)

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