P1 PATHOLOGY Flashcards
common risk factor for developing Barrett oesophagus
GERD
who usually presents with barrett disease
white males , 40-6- years
Regular screening done with barrett patients is to
Detect oesophageal cancer ( dysplasia ) early
what type of oesophageal cancer does barrett usually confers to
Oesophageal adenocarcinoma
Epithelial dysplasia increase with
duration of symptoms
Patient age
what medical invasive procedures are done to confirm diagnosis
Endoscopy
Biopsy taken for Histology
Endoscopically will recognize
patches of red , velvety mucosa
those patches are due to altering from -to
altering from smooth squamous to light brown columnar mucosa
barrett oesophagaus is histologically Characterised by
presence of mucin containing goblet cells
most common types of oesophageal cancer
adenocarcinoma
S.C.C
risk factors for adenocarcinoma
History of GERD / barrett
smoking
obese
Previous radiation therapy
gender at more risk
males
Ethnic groups at higher risk
white people
Precursor of adenocarcinoma
barrett disease
location that is is usually affected
distal part of the oesophagus / lower part
Tumors in adenocarcinoma typically produce
mucin
Patient will present with
Dysphagia
chest pain
Weight loss
vomiting
risk factors for S.C.C
smoking / Alcohol
Poverty / oesophageal injury
achlasia / plummer-vinson syndrome
very hot beverages / previous radiation to mediastinum
gender at higher risk
males
age groups at higher risk
older than 45 years
Ethnic groups at higher risk
African Americans
Precursors for S.C.C
Alcohol consumption
Nutritional deficiencies
what viral infection can be considered as a precursor for S.C.C
HPV
location that is usually affected
middle third part
