onco-para neoplastic syndrome Flashcards
Most common para neoplastic syndrome
Hypercalcemia
Para neoplastic syndrome
SIADH Syndrome of ectopic ACTH production Subacute sensory neuropathy Hypercalcemia Hypertrophic pulmonary osteoarthropathy Hypercoagulable state Adrenal insuff Migratory thrombophlebitis Ectopic HCG production Eaton-Lambert Syndrome Fever and neutropenia Clubbing No bacterial thrombotic endocarditis Tumor lysis syndrome
Hypercalcemia occurs in about 10% of the cancer patients.. Most commonly in..
Cancer of lungs breast head and neck Kidney Myeloma (bone marrow)
Most common mechanism of hypercalcemia as para neoplastic syndrome
Bone resorption mediated by parathormone-related proteins
S&s in hypercalcemia
Fatigue
Anorexia
Constipation
Weakness
Cytokines that acts locally in tumor in pts with hypercalcemia
IL-1
IL-6
Transforming GF-B
Syndrome of inappropriate antidiuretic hormone is induced by…
Action of arginine vasopressin produced by certain tumors
Most common tumor involved in pts with SIADH
Small cell carcinoma of the lungs
SIADH is characterized by
Hyponatremia
Inappropriate concentrated urine
High urine NA secretion in the absence of volume depletion
S&s of SIADH
Confusion Lethargy Irritability Personality changes Weakness Anorexia Depression
Causes of adrenal insufficiency
- Infiltration of adrenals by tumor
2. Adrenal destruction by hemorrhage
S&s of adrenal insuff
Nausea and vomiting
Anorexia
Orthostatic hypotension
Syndrome of ectopic ACTH secretion is characterized by..
Hyperadrenocorticalism due to ectopic ACTH production
S&s of Syndrome of ectopic ACTH secretion
Cushingoid feature Severe weakness Hypertension Edema Weight loss
It is characterized by proximal limb weakness that improves with repeat contraction
Eaton-lambert syndrome
Eaton-lambert syndrome is most commonly asso with…
Small cell lung carcinoma
A peripheral neuropathy characterized by progressive involvement of all sensory modalities with areflexia and sensory ataxia
Subacute sensory neuropathy
Subacute sensory neuropathy is most commonly asso with…
Small cell lung carcinoma
In nonbacterial thrombotic endocarditis, which heart valve is commonly involved?
Mitral valve
Nonbacterial thrombotic endocarditis may result to
Emboli to CNS, kidneys and coronary arteries
Nonbacterial thrombotic endocarditis is commonly asso with…
Adenocarcinoma
Bronchioalveolar cell Ca
It is characterized by the release of large amt of NA breakdown products (chiefly uric acid), K, P, lactic acid due to rapid destruction of tumor cells when rapidly growing tumor are treated with effective chemotherapy regimen.
Tumor lysis syndrome
In tumor lysis syndrome, high phosphate may lead to..
Hypocalcemia
In tumor lysis syndrome, high uric acid (acidosis) may lead to
Its precipitation in renal tubules which may lead to renal failure which in turn may exacerbate hyperkalemia
Chemo pts
NA, Ca, PO4, K, urinalysis
