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Med Prep > iv anes, gen anes, local anes > Flashcards

iv anes, gen anes, local anes Flashcards

0
Q

Ketamine antagonize what receptors

A

Nmda receptors

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1
Q

All IV anes acts on gaba receptor exc

A

Ketamine

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2
Q

Rate of transfer into the brain and the anesthetic effect is regulated by the ff factors

A
  1. Inbound drug
  2. Reduced cerebral blood flow
  3. Non-ionized
  4. Lipid soluble
  5. Rapid injection
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3
Q

Hyperventilation will increase/decrease protein binding

A

Decrease protein binding= increase unbound drug = increase anes effect

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4
Q

T or F: protein binding is affected by changes in ph

A

True

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5
Q

CBF is reduced becoz Of low/high CO

A

Low CO.

Anes effect is delayed but enhanced

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6
Q

T or F: rapid administration also affects the extent of cvs and respiratory side effects

A

True

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7
Q

Alkylthenol cmpd

A

Propofol

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8
Q

Propofol: insoluble/soluble in water

A

Insoluble.

Requires egg lecithin emulsion 1%

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9
Q

Propofol: pain / no pain on injection

A

Pain on injection

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10
Q

Feeling of week being andn euphoria

A

Propofol

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11
Q

Propofol: increase/decrease CMRCO2, CBF, ICP, cerebral perfusion rate

A

Decrease

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12
Q

Drug of choice if LMA is used

A

Propofol

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13
Q

With anticonvulsant and antiemetic prop

A

Propofol

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14
Q

Asso with release of histamine and anaphylactoid reaction

A

Propofol

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15
Q

Propofol EEG. Frequency and amplitude and duration of seizures

A

Increase amplitude
Decrease frequency
Decrease duration of seizure

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16
Q

Propofol anes is induced sec

A

40-60s

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17
Q

Ketamine anes induced sec

A

30-60s

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18
Q

Ketamine: soluble/insoluble to water

A

Soluble to water

Lipid soluble also

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19
Q

Phencyclidine

A

Ketamine

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20
Q

Dissociative anes.. Rather than generalized depression of cns

A

Ketamine

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21
Q

Ketamine EEG. Alpha and tetha

A

Loss of alpha waves

More tetha waves

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22
Q

Ketamine: increase/decrease CMRCO2, CBF, ICP, cerebral perfusion rate

A

Increase

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23
Q

Propofol: increase/decrease arterial P, HR

A

Decrease

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24
Q

Ketamine: increase/decrease arterial P, HR

A

Increase

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25
Q

Inotropic effect of Propofol

A

(-) inotropic effect

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26
Q

Inotropic effect of ketamine

A

(+) inotropic

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27
Q

Propofol/ketamine: apnea is more common

A

Propofol

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28
Q

Propofol/ketamine: transient apnea, ventilation is maintained

A

Ketamine

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29
Q

Propofol/ketamine: no effect on bronchial ms tone

A

Propofol

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30
Q

Propofol/ketamine: bronchodilation

A

Ketamine

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31
Q

Propofol/ketamine: decrease ms tone, movement on stimulation

A

Propofol

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32
Q

Propofol/ketamine: increase ms tone, spont. Movement

33
Q

Propofol/ketamine: no GI effect. N and V uncommon

34
Q

Propofol/ketamine: increase salivation

35
Q

Propofol/ketamine: no uterine effect, cross PBB

36
Q

Propofol/ketamine: uterine relaxation, cross PBB

37
Q

Propofol/ketamine: night,are and hallucination

38
Q

Propofol/ketamine/etomidate/thiopental: delay disappearance of eyelash

39
Q

Propofol/ketamine/etomidate/thiopental:

overdosage may lead to loss of verbal contact

40
Q

Propofol/ketamine/etomidate/thiopental:

Recovery of consciousness is rapid

41
Q

Propofol/ketamine/etomidate/thiopental:

Minimal hang-over effect

42
Q

The pressor response to tracheal intubation is attenuated to a greater extend by

43
Q

T or F: ventilatory depression of Propofol is more marked if opioids are administered

44
Q

Propofol/ketamine/etomidate/thiopental:

Decrease HBF and renal function

45
Q

Propofol/ketamine/etomidate/thiopental:

Liver function test not deranged

46
Q

Propofol/ketamine/etomidate/thiopental:

Decrease cortisol

47
Q

Metabolite of Propofol excreted by kidney

A

Glucoronide

48
Q

Terminal elimination half life of Propofol

49
Q

Effective half life of Propofol

50
Q

Distribution and clearance of Propofol are altered by admin of

51
Q

AE of Propofol

A

CV and respi depression
Excitatory phenomena
Pain on injection
Allergic reaction

52
Q

Propofol/ketamine/etomidate/thiopental:

Indicated if rapid recovery of consciousness is required

53
Q

T or F: rapid redistribution and metab of Propofol may increase risks of awareness during tracheal intubation

54
Q

Most suitable TIVA

55
Q

Propofol/ketamine/etomidate/thiopental:

Potent somatic analgesic

56
Q

Propofol/ketamine/etomidate/thiopental:

Amnesia persists for 1hr after recovery of consciousness

57
Q

Positive inotropic effect of ketamine is due to

A

Ca influx and cAMP

58
Q

Propofol/ketamine/etomidate/thiopental:

Increased myocardial sensitivity to epinephrine

59
Q

Sympathetic stim in ketamine is decrease/increase

A

Decrease sympa
VasoD alpha adrenergic receptor
VasoC beta adrenergic receptor

60
Q

Propofol/ketamine/etomidate/thiopental:

Transient Increase IOP

61
Q

Propofol/ketamine/etomidate/thiopental:

Hypertension and tachycardia.

62
Q

Propofol/ketamine/etomidate/thiopental:

Prolonged recovery

63
Q

Propofol/ketamine/etomidate/thiopental:

Increase ICP

64
Q

Propofol/ketamine/etomidate/thiopental:

Decrease ICO

65
Q

T or F: ketamine is unsuitable for pt with preexisting hypertension, IHD and severe cardiac decompensation

66
Q

Lorazepam
Diazepam
Midazolam

A

Benzodiazepine

67
Q

Benzo which is water insoluble

A

Diazepam

Lorazepam

68
Q

Benzo which is water soluble

69
Q

Benzo with pain in injection

A

Diazepam

Lorazepam

70
Q

Benzo with minimal pain on injection

71
Q

Benzo used for continuous infusion

72
Q

Propofol/ketamine/etomidate/benzo:

Potent anticonvulsant, treatment status epilepticus

A

Benzodiazepine

73
Q

Carboxylated imidazole

74
Q

Propofol/ketamine/etomidate/thiopental:

Myo clonic movement are common

75
Q

Propylene glycol means

A

Pain on injection

Diazepam, lorazepam, etomidate

76
Q

Propofol/ketamine/etomidate/thiopental:

Maintain CBF

77
Q

Propofol/ketamine/etomidate/thiopental:

Minimal depression of ventilation

78
Q

Propofol/ketamine/etomidate/thiopental:

No release of histamine

79
Q

Propofol/ketamine/etomidate/thiopental:

Inhibit plt function and prolong bleeding time

80
Q

Drug of choice for pt with reactive airwax disease

Med Prep (52 decks)

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