gyne- cervical and ovarian ca Flashcards
Cervical SCCA/AdenoCa: associated with early and freq sexual contact
SCCA
Cervical SCCA/AdenoCa: most common cervical ca
SCCA
Cervical SCCA/AdenoCa: not affected by sexual contact
Adenoca
Cervical SCCA/AdenoCa: associated with sexual contact and cervical viral infection
SCCA
Subtypes of cervical SCCA
Large cell( keratinizing and non keratinizing)
Small cell
Verrucous
Cervical ca associated with diethylstilbestrol exposure
Clear cell cervical ca
Subtypes of cervical adenoca
Typical (endocervical) Endometrioid Clear cell Adenoid cystic Adenoma malignum
Basaloid cylindroma
Adenoid cystic of cervical ca
Minimal deviation adenoca
Adenoma malignum of cervical ca
Mixed cervical ca
Adenosquamous
Glassy cell
Keratinizing/nonkeratinizing:
IRREG NESTS of squamous cells forming several PEARLS separated by fibrous stroma
Keratinizing
Keratinizing/nonkeratinizing:
Discrete islands of UNIFORM large cells with abundant CYTOPLASM separated by fibrous stroma
Nonkeratinizing LCCA
How many years younger is Small cell cervical ca to SCCA?
10y.o
Small cell cervical ca is an aggressive ca which may metastasize to…
Bone
Liver
Skin
Brain
Verrucous ca is a warty, large, bulbous mass wc is similar to
Vulva
Risk factors for cervical adenocarcinoma
HPV DNA
OCP use
Lack of cervical cytologic screening
Clear cell adenoca of cervix is histologically similar to…
Vagina
Ovary
T or F: clear cell adenoca can develop simultaneously
True
Adenoid cystic cervical ca resembles…
Cylindroma of salivary gland or breast origin
BCCa of Skin
T or f: mixed cervical ca is a hospital diagnosis
True
T or f: adenosquamous ca occur freq in nonpregnant women
False. Occurs in pregnant women
Glass cell cervical ca is a SMALL/LARGE cell containing cyto with ground glass appearne which tends to metastasize to ____
Large cells
Metastasize in lymph nodes
Mixed cervical ca
Adenosquamous ca
Glass cell ca
Clinical features of cervical ca
Bleeding or brownish discharge
Ff douching or intercourse
Spont in between men’s
Late manifestations of cervical ca which usually means extensive spread of ca
Back pain
Loss of appetite
Weight loss
Age of cervical ca
40-60
Preinvasive intraepithelial cervical ca age
20
Diagnostic tests for cervical ca
Pap smear
Colposcopy
Endocervical curettage
Biopsy
Excisional/punch biopsy is preferable in cervical ca
Excisional biopsy
Helps in selecting the biopsy sight where growth is a obvious in cervical ca
Schiller’s test/acetic acid
Biopsy for early cases of cervical ca
Cone biopsy
Used in VIA
3-5% Acetic acid
Used in schiller’s test
Iodine
Characteristic of good screening tool
High sn and sp Applied to asymptomatic women Diagnosis of disease at premalignant Easily applied to large grp Reasonable cost
Adeq specimen of Pap smear
Squamo columnar junction
Sn and sp of Pap smear
Sn 50%
Sp 95%
Best yield Pap smear
Arye spatula plus endocervical brush
Developed as a uniform system of terminology which provides clear guidance for clinical management
Bethesda system
Most imp quality assurance of bethesda system
Evaluation of specimen adequacy
When the degree of atypia is not sufficient to warrant diagnosis of SIL
ASC
Management for ASC
Observe, ff up
ASC-H have a significantly higher predictive value for ___ than ASC-US
CIN 2 or 3
Management for ASC-US and ASC-H
Biopsy
