(OLD) IASM 28: Connective Tissues Flashcards
Which germ layer is connective tissue originated?
Mesoderm
Are there junctions between connective tissues?
No.
What are the three types of connective tissues?
Connective Tissue Proper
Specialized Connective Tissues
Embryonic Connective Tissues
What is included in the connective tissue proper?
Name 4
Lamina Propria
Dermis of Skin
Tendon
Ligaments
What are in the specialized connective tissues?
Name 3
Cartilage and bone
Blood and haematopoietic tissues
Adipose tissues
What are in the embryonic connective tissues
Name 2
Mesenchyme
Mucous connective tissue
Proteoglycan molecules are highly charged. What is the function of this?
Holding lots of water
what are functions of the connective tissues in the body?
Name 4
Supports epithelial tissue Connect tissues or organs Protection by physical barrier formation Tissue repair Regulation of behaviour of cells by the extracellular matrix
Which type of collagen is the most abundant in human body?
Type I
where is the type I collagen in human body
Name 4
tendon
ligament
skin
bone
Which two things does a tendon connect
Muscle
Bone
What is tropocollagen made up of
Components of the 3 chains of the triple helix
Alpha 1
Alpha 1
Alpha 2
Forming a triple helix
What amino acids are tropocollagen abundant in
Name 3
Glycine
Proline
Hydroxyproline
What cells contain type I collagen
Name 2
Fibroblasts
Osteoblasts
Where is type I collagen located in the body?
Name 4
Tendon
Ligament
Dermis of skin
Bones
What cell contain type II collagen
Chondroblasts
Where is type II collagen found in body
Hyaline cartilage
what cell contain type III collagen
Fibroblasts
Where is type II collagen located in the body
Reticular fiber
What cell contain type IV collagen
Epithelial cells
Where is type IV collagen in the body
Basal lamina
What is the function of reticular fibre
Form extensive network to support soft organs
Lymph node, spleen, red bone marrow, liver
Is reticular fibre visible under Hematoxylin and Eosin staining
No
Is reticular fibre visible under silver stain
Yes
What term is called for things visible by silver stain
Argyrophilic
What does PAS stain usually do
Stain polysaccharides
Is reticular fibre PAS positive or negative? and Why?
Positive
High content of glycoproteins
What is the structure of elastic fibres?
Amorphous core of elastin
Surrounded by microfibrils/ fibrillin
With cross-links between elastin molecules
Is elastic fibre stained by H&E stain
No
where are the elastic fibres located in the body
Name 3
Loose connective tissue (Loose network)
aorta walls
Ligamentum flavum in vertebral column
What are the types of connective tissues?
Name 3
Loose/ areolar connective tissue
Dense irregular connective tissue
Dense regular connective tissue
Where are the loose/ areolar connective tissue
Name 3
Lamina propria
Mesentery
Wharton’s jelly
where is lamina propria in the body
digestive or respiratory tract
where is mesentery in the body
GI tract
where is Wharton’s jelly in the body
Umbilical cord
Where is the dense irregular connective tissue
Dermis of skin
Where is dense regular connective tissue
Name 3
Tendon
ligament
Aponeurosis (attaching muscle to bone)
when active, called fibroblasts.
What is it called when it is quiescent?
Fibrocyte
What is the function of the fibroblast
Name 5
Synthesize fibrous component Synthesize ground substance Response to tissue damage Synthesize new extracellular matrix Formation of scar tissue during wound healing
Is macrophage specific or non-specific response
Non-specific
Macrophages contain _______ for digestion
Lysosomes
what are macrophages derived from?
Monocytes
what is epitope?
small copy of digested antigen
what is used to digest antigen in macrophage?
Lysosome
What is used to present the epitope to the T-cell receptor
MHC II Protein
are plasma cells basophilic? why?
Yes
There are a lot of rough endoplasmic reticulum
What are the two types of adipose tissues
Multilocular adipocyte
Unilocular adipocyte
what is the characteristic of unilocular adipocytes
Single large fat droplets
what are characteristics of multilocular adipocytes
Name 2
Brownish colour: More blood vessels and mitochondria
Multilocular adipose tissues are greatly reduced in _________ and more in _________
Adults; infants
What type of cell is included in the cellular component of the connective tissues?
Immune Defence Cells
What is included in non-cellular component of connective tissue?
Fibrous Component—?
Ground Substance—-?
Fibrous component:
Collagen
Reticular Fiber
Elastic Fiber
Ground Substance: (Form gel-like matrix)
Proteoglycan (Core protein + GAG)
Glycoproteins