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MBBS IASM > (OLD) IASM 28: Connective Tissues > Flashcards

(OLD) IASM 28: Connective Tissues Flashcards

1
Q

Which germ layer is connective tissue originated?

A

Mesoderm

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2
Q

Are there junctions between connective tissues?

A

No.

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3
Q

What are the three types of connective tissues?

A

Connective Tissue Proper
Specialized Connective Tissues
Embryonic Connective Tissues

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4
Q

What is included in the connective tissue proper?

Name 4

A

Lamina Propria
Dermis of Skin
Tendon
Ligaments

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5
Q

What are in the specialized connective tissues?

Name 3

A

Cartilage and bone
Blood and haematopoietic tissues
Adipose tissues

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6
Q

What are in the embryonic connective tissues

Name 2

A

Mesenchyme

Mucous connective tissue

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7
Q

Proteoglycan molecules are highly charged. What is the function of this?

A

Holding lots of water

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8
Q

what are functions of the connective tissues in the body?

Name 4

A 
Supports epithelial tissue
Connect tissues or organs
Protection by physical barrier formation
Tissue repair
Regulation of behaviour of cells by the extracellular matrix
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9
Q

Which type of collagen is the most abundant in human body?

A

Type I

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10
Q

where is the type I collagen in human body

Name 4

A

tendon
ligament
skin
bone

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11
Q

Which two things does a tendon connect

A

Muscle

Bone

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12
Q

What is tropocollagen made up of

Components of the 3 chains of the triple helix

A

Alpha 1
Alpha 1
Alpha 2
Forming a triple helix

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13
Q

What amino acids are tropocollagen abundant in

Name 3

A

Glycine
Proline
Hydroxyproline

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14
Q

What cells contain type I collagen

Name 2

A

Fibroblasts

Osteoblasts

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15
Q

Where is type I collagen located in the body?

Name 4

A

Tendon
Ligament
Dermis of skin
Bones

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16
Q

What cell contain type II collagen

A

Chondroblasts

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17
Q

Where is type II collagen found in body

A

Hyaline cartilage

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18
Q

what cell contain type III collagen

A

Fibroblasts

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19
Q

Where is type II collagen located in the body

A

Reticular fiber

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20
Q

What cell contain type IV collagen

A

Epithelial cells

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21
Q

Where is type IV collagen in the body

A

Basal lamina

22
Q

What is the function of reticular fibre

A

Form extensive network to support soft organs

Lymph node, spleen, red bone marrow, liver

23
Q

Is reticular fibre visible under Hematoxylin and Eosin staining

A

No

24
Q

Is reticular fibre visible under silver stain

A

Yes

25
Q

What term is called for things visible by silver stain

A

Argyrophilic

26
Q

What does PAS stain usually do

A

Stain polysaccharides

27
Q

Is reticular fibre PAS positive or negative? and Why?

A

Positive

High content of glycoproteins

28
Q

What is the structure of elastic fibres?

A

Amorphous core of elastin
Surrounded by microfibrils/ fibrillin
With cross-links between elastin molecules

29
Q

Is elastic fibre stained by H&E stain

A

No

30
Q

where are the elastic fibres located in the body

Name 3

A

Loose connective tissue (Loose network)
aorta walls
Ligamentum flavum in vertebral column

31
Q

What are the types of connective tissues?

Name 3

A

Loose/ areolar connective tissue
Dense irregular connective tissue
Dense regular connective tissue

32
Q

Where are the loose/ areolar connective tissue

Name 3

A

Lamina propria
Mesentery
Wharton’s jelly

33
Q

where is lamina propria in the body

A

digestive or respiratory tract

34
Q

where is mesentery in the body

A

GI tract

35
Q

where is Wharton’s jelly in the body

A

Umbilical cord

36
Q

Where is the dense irregular connective tissue

A

Dermis of skin

37
Q

Where is dense regular connective tissue

Name 3

A

Tendon
ligament
Aponeurosis (attaching muscle to bone)

38
Q

when active, called fibroblasts.

What is it called when it is quiescent?

A

Fibrocyte

39
Q

What is the function of the fibroblast

Name 5

A 
Synthesize fibrous component
Synthesize ground substance
Response to tissue damage
Synthesize new extracellular matrix
Formation of scar tissue during wound healing
40
Q

Is macrophage specific or non-specific response

A

Non-specific

41
Q

Macrophages contain _______ for digestion

A

Lysosomes

42
Q

what are macrophages derived from?

A

Monocytes

43
Q

what is epitope?

A

small copy of digested antigen

44
Q

what is used to digest antigen in macrophage?

A

Lysosome

45
Q

What is used to present the epitope to the T-cell receptor

A

MHC II Protein

46
Q

are plasma cells basophilic? why?

A

Yes

There are a lot of rough endoplasmic reticulum

47
Q

What are the two types of adipose tissues

A

Multilocular adipocyte

Unilocular adipocyte

48
Q

what is the characteristic of unilocular adipocytes

A

Single large fat droplets

49
Q

what are characteristics of multilocular adipocytes

Name 2

A

Brownish colour: More blood vessels and mitochondria

50
Q

Multilocular adipose tissues are greatly reduced in _________ and more in _________

A

Adults; infants

51
Q

What type of cell is included in the cellular component of the connective tissues?

A

Immune Defence Cells

52
Q

What is included in non-cellular component of connective tissue?
Fibrous Component—?
Ground Substance—-?

A

Fibrous component:
Collagen
Reticular Fiber
Elastic Fiber

Ground Substance: (Form gel-like matrix)
Proteoglycan (Core protein + GAG)
Glycoproteins

MBBS IASM (46 decks)

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